아스피린 복용 후 발생한 급성 난청과 이명 1예
Acute Sensorineural Hearing Loss and Tinnitus with Aspirin: A Case Report
Salicylate (aspirin) causes ototoxic side effects in some patients, such as bilateral mildto moderate sensorineural hearing loss and tinnitus although its ototoxic mechanisms stillremain largely unclear. We report about one case with acute sensorineural hearing lossanf tinnitus after one week of low dose aspirin therapy. Audiogram revealed a mild sensorineuralhearing loss at 35.0 dBHL in the right ear. Tinnitus became louder more andmore, and sounded like a unilateral or bilateral high-pitch noise with each recurrence persistingfor five minutes or longer. Audiologic problem of this case resolve within two orthree days after the aspirin is discontinued. Generally, ototoxicity of salicylate manifestsas bilateral, flat to high-frequency sensorineural hearing loss, and the risk of ototoxicityincreases with higher doses and prolonged treatment course. But our case tend to suggestthat symptoms of ototoxicity also might be occur in patients in even low dose salicylatewith variable audiologic finding case tend to suggest that symptoms of ototoxicity alsocan occur in patients in even low dose salicylate use with variable audiologic finding.Further work on the relationships between plasma salicylate concentrations and ototoxicityis required.
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