본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

한국인체미용예술학회지 , 2010년, pp.125 - 135  
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Tungstate 첨가식이 조건에 따른 PPD 도포가 흰쥐 피부조직 손상에 미치는 영향
Effect of Condition of Tungstate Supplemented Diet on Damaged Rat Skin by PPD

이상희  장정애 
  • 초록

    Xenobiotics such as p-pheylenediamine (PPD), one of hair dye ingredients, have different responses to human body dependant on absorption, distribution, metabolism, excretion, dose and duration of xenobiotics. PPD causes systemic dermatitis and bladder cancer so on. This study is performed to investigate the severe degree of skin toxicity of applied PPD in tungstate induced xanthine oxidase(XO) deficient model as for the exposed duration. PPD (2.5% PPD in 2% NH4OH) were applied to rat skin (25mg/16.5㎠) two or six times every other day in rats fed tungstate diet for 4 days or 12 days and standard diet. There were determined the increased activity of acid phosphatase (ACP) and the increased content of lipid peroxide (LPO) in PPD applied group two times fed tungstate diet for 4 days(PTC) or six times for 12 days(PPTTC) compared with PPD applied group two(PSC) or six times(PPSC) respectively, and The skin tissue was severe as long as the administrated duration was. In the experimental conditions, PTC and PPTTC showed more severe skin damage compared with the PSC and PPSC respectively wheres XO activity was almost not detected in PTC and PPTTC. In addition, there were more decreased rates of the activities of ROS scavenging enzymes and glutathione(GSH) contents in PTC to PTTC compared with PSC to PPSC.In conclusion, the increased severity of skin tissue may be due to the excessive reactive oxygen species(ROS) by the long exposed durations of PPD application and tungstate supplemented diet.


 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
유료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.