새로운 항우울제의 부작용과 약물학적 처치- 드물지 않지만 잘 인지되지 않는 부작용을 중심으로 -
Adverse Effects and Pharmacological Management of Newer Antidepressants - Focusing on Common but Under-Recognized Adverse Effect -
Nowadays newer antidepressants are commonly used in clinical practice, since they are as effective as tricyclic antidepressant,but show less adverse effects. However there are many unexpected adverse effects of these drugs. It is one of the most commoncauses of treatment failure. I reviewed these adverse effects and pharmacological management focusing on common butunder-recognized adverse effects of newer antidepressant. I reviewed newer antidepressant-induced sleep related movementdisorder, sweating, tremor, abnormal bleeding. In this paper, newer antidepressants include selective serotonin reuptake inhibitor(fluoxetine, fluvoxamine, citalopram, escitalopram, sertraline, paroxetine), serotonin norepinephrine reuptake inhibitor(venlafaxine, duloxetine), norepinephrine and dopamine reuptake inhibitor (bupropion), noradrenergic and specific serotonergicantidepressant (mirtazapine), and reversible inhibitor of monoamine oxidase A (moclobemide). I suggest that psychiatristsshould know not only well-recognized but also under-recognized common adverse effects and their pharmacological managementof newer antidepressants, so that it will be helpful to treat patients with psychiatric illness using newer antidepressantsand to make better outcome.
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