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Noble synthesis of the [1,4]-oxazine derivatives and its mechanistic study 원문보기

  • 저자

    Song, Sang-Yong

  • 학위수여기관

    昌原大學校

  • 학위구분

    국내석사

  • 학과

    화학과

  • 지도교수

  • 발행년도

    2002

  • 총페이지

    119장.

  • 키워드

  • 언어

    eng

  • 원문 URL

    http://www.riss.kr/link?id=T8935912&outLink=K  

  • 초록

    The [1,4]-oxazine structure is one of important backbone in natural products and biological activity compounds. However, there are fewer synthetic methods are reported. Herein, we are introducing of noble and convenient synthetic method of [1,4]-oxazine and their derivatives using 3-halo-4-hydroxy-prop-3-en-2-one / dihalo-hydroxy-but- 3-en-2-one and N-substituted-2-hydroxy / halo acetamide compound as starting materials. In addition, this method can be adaptable to synthesis of pyridazine, pyridine and naphthoquinone fused [1,4]- oxazines. Also, we are suggested that this reaction mechanism is followed via Michael type addition or SN2 type reaction between 3-halo-4-hydroxy-prop-3-en-2-one/dihalo-hydroxy-but-3-en-2-one and N- substituted-2-hydroxy / halo acetamide compound and then inter- molecular nitrogen oriented migration.


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