Tyrosinase 억제효과가 뛰어난 Oxamate derivative salt에 관한 연구
Studies on oxamate derivative salts with anti-tyrosinase activity
Tyrosinase PPO Oxamate derivative salt 색소;
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Mushroom tyrosinase(EC 188.8.131.52) is a copper containing oxidase that catalyzes both the hydroxylation of tyrosine into o-phenols and the oxidation of o-quinones, and then forms brown or black pigments. Nowadays mushroom tyrosinase has become popular because it is readily available and useful in a number of applications. In the present study, effect of oxamate derivative salts on the activity of mushroom tyrosinase for the catalysis of L-tyrosine was carried out. A kinetic analysis showed that the oxamate derivatives were mixed type inhibitors. The order of inhibition activity was : kojic acid>disodium salt>monosodium salt>arbutin. Recently, the use of kojic acid was prohibited because it was proved to be a carcinogenic material.