관상동맥질환과 심장판막질환에서 혈액학적 위험표지자의 비교
Comparison of hematologic risk factors in coronary artery disease and valvular heart disease
관상동맥질환 심장판막질환 혈액학 위험표지자;
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Backgrounds: Many studies have been tried to evaluate the relation between coronary artery disease and risk factors and/or specific markers in blood. The study was designed to compare clinically available serologic risk markers between coronary heart disease and valvular heart disease, such as inflammatory markers, lipid profile, autoantibodies and procoagulants. Materials and Methods: A total of 103 surgical patients were included in the study (coronary heart disease 71, valvular heart disease 32). The parameters were collected during hospitalization before the surgery; CRP(C-reactive protein), ESR(Erythrocyte Sedimentation Rate), ASLO(Antistreptolysin-O), RF(Rheumatoid factor), VDRL(Venereal disease research laboratory test), FANA (Fluorescent anti-nuclear autoantibody), ANCA(Anti-neutrophil cytoplasmic autoantibody), CG(Cryoglobulin), total cholesterol, total lipid, phospholipid, triglyceride, HDL-cholesterol, BT(Bleeding time), PT(Prothrombin time), aPTT(Activated partial thromboplastin time). Each parameter was analyzed for statistical significance in difference between two groups. Results: No differences were noted in inflammatory markers, autoantibodies, and procoagulants in either gender or age distribution, In lipid profiles, total cholesterol level was significantly higher in patients younger than 49 years old with coronary heart disease. Conclusion: In this study, most of clinically available serologic risk makers were not different between coronary and valvular heart disease. A further study is required with refined laboratory parameters as well as understanding the disease mechanism to evaluate the preoperative serologic risk markers in coronary heart disease.