성인에서 혈청 Gamma-Glutamyltransferase와 심혈관계 질환의 위험요인과의 관련성
Relationship between Serum Gamma Glutamyltransferase and Cardiovascular Disease Risk Factors
심혈관계 질환 성인 혈청;
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To investigate gamma glutamyltransferase(GGT) and risk factors of cardiovascular disease. a total of 1,882(male 630, female 552) adults were recruited from November 2003 to January 2004. A self-administered questionnaire survey on life style was also done. Fasting blood samples were collected to get the data on clinical variables. Geometric mean of GGT in men (33.8 U/L) was significantly higher than 18.1 U/L in women(p=0.001). By simple analysis, BMI(p=0.001), smoking(p=0.001), amount of smoking(p=0.002), alcohol(p=0.001), exercise(p=0.009) and coffee intake(p=0.021) were significantly associated with the serum GGT. In women, those were BMI(p=0.001), smoking(p=0.044), alcohol(p=0.006), exercise(p=0.022), meat intake(p=0.045), and menopause(p=0.001). By the multiple regression analysis after controlling for age, BMII, alcohol, smoking, exercise, and coffee intake, significant risk factors related with serum GGT were SBP(p=0.030), DBP(p=0.033), FBS(p=0.001), uric acid(p=0.025), total cholesterol(p=0.001), and triglyceride (p=0.001) in men. And those in women after controlling for age, BMI, alcohol, exercise, meat intake, and menopause were SBP(p=0.024), FBS(p=0.001), uric acid(p=0.002), and triglyceride(p=0.001). In conclusion, it is recommended that an integrated program for modifying life styles should be started to reduce the GGT level for the prevention of cardiovascular disease.