공막 내 삽입한 생체분해성 고분자 매트릭스를 이용한 스테로이드 지속 방출법 개발
Development of the biodegradable intrascleral implant for sustained release of steroids
안구질환 생체분해성 고분자 매트릭스;
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In order to treat inflammatory and proliferative disorders of posterior segment of eye, the author evaluated the biodegradable intrascleral implant for slow releasing of triamcinolone acetonide (TA). The intrascleral implant (1 mm in thickness and 3 mm in diameter) was made of alginic acid and PLA (poly(D,L-lactide)) containing 4 mg of TA. In vitro release of TA was evaluated by liquid chromatography-mass spectrometer. To evaluate in vivo release of TA, the implants were placed into scleral pockets in the 18 rabbit eyes, and the concentration of TA in the aqueous humor, vitreous, and retina-choroid were measured by HPLC at 1, 2, 4, 8, and 12 weeks after implantation. The toxicity and biocompatibility of the implant were evaluated by slit lamp biomicroscopic examination, IOP, electroretinography, and light microscopy. In vitro study demonstrated that the implant released TA in controlled manner for at least 8 months. The TA concentration was greater in vitreous than retina-choroid in vivo study, which remained constant after 8 to 12 weeks. The TA was not detected in aqueous humor. No significant toxicity to the retina was observed. These results suggest that the intrascleral implant with TA would be a promising system for delivery of steroid to the posterior segment of eye in cases of inflammatory or proliferative disorders of posterior segment.