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심근경색과 Chlamydophila pneumoniae의 관련성 원문보기
Association of myocardial infarction and chlamydophila pneumoniae

  • 저자

    은상진

  • 학위수여기관

    경북대학교 대학원

  • 학위구분

    국내박사

  • 학과

    의학과 임상병리학전공

  • 지도교수

  • 발행년도

    2004

  • 총페이지

    38, iiip.

  • 키워드

    임상병리 심근경색 Chlamydophila pneumoniae;

  • 언어

    kor

  • 원문 URL

    http://www.riss.kr/link?id=T10045632&outLink=K  

  • 초록

    There is growing evidence linking Chlamydophila pneumoniae infection to myocardial infarction. However, the data remain inconclusive so, the author intended to assess whether C. pneumoniae is associated with acute myocardial infarction by measuring anti-C. pneumoniae IgG and IgM antibodies using enzyme-linked immunosorbant assay (ELISA) and microimmunofluorescence (mIF) and detecting C. pneumoniae DNA using polymerase chain reaction (PCR). Blood and peripheral mononuclear cells (PMNCs) of 54 cases of acute myocardial infarction (MI), 33 cases of old MI and 60 normal controls were collected. Sera were examined in ELISA and mIF and PMNCs in PCR. Seropositivity of anti-Chlamydophila pneumoniae IgM antibody by ELISA are shown 10.0% in control group, 14.8% (OR=1.57, 95% confidence interval [CI] 0.51-4.84, P=0.570) in MI and 21.2% (OR=2.42, 95% CI 0.74-7.94, P=0.210) in old MI group, respectively. Seropositivity of anti-Chlamydophila pneumoniae IgM antibody by mIF (Fuller Lab, Cal, USA: mIF-F) are shown 8.3% in control group, 38.9% (OR=7.00, 95% CI 2.41-20.34, P=0.000) in MI and 24.2% (OR=3.52, 95% CI 1.05-11.84, P=0.058) in old MI group, respectively. Seropositivity of anti-Chlamydophila pneumoniae IgM antibody by mIF (home-made: mIF-H) are shown 5.0% in control group, 29.6% (OR=8.00, 95% CI 2.18-29.34, P=0.001) in MI and 6.1% (OR=1.23, 95% CI 0.19-7.73, P=1.000) in old MI group, respectively. Seropositivity of anti-Chlamydophila pneumoniae IgG antibody by ELISA are shown 58.3%, in control group, 87.0% (OR=4.80, 95% CI 1.86-12.35, P=0.001) in MI and 87.9% (OR=2.42, 95% CI 0.74-7.94, P=0.210) in old MI group, respectively. Seropositivity of anti-Chlamydophila pneumoniae IgG antibody by mIF-F are shown 75.0% in control group, 100% in MI and old MI group, respectively. Seropositivity of anti-Chlamydophila pneumoniae IgG antibody by mIF-H are shown 60.0% in control group, 92.6% (OR=8.33, 95% CI 2.66-26.11, P=0.000) in MI and 87.9% (OR=4.83, 95% CI 1.51-15.51, P=0.005) in old MI group, respectively. Anti-Chlamydophila pneumoniae IgM and IgG antibodies titers distribution in MI and old MI by mIF-H method show increased tendency than those of control group. And analyses of reproducibility between two of three anti-C. pneumoniae antibodies by ELISA and two mIF methods give poor results (κ


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