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굴곡성 기관지경을 이용한 기관내 삽관시 나타나는 심혈관계에 반응에 대한 alfentanil의 영향 원문보기
Effect of Alfentanil on Cardiovascular Response to Bronchoscopic Endotracheal Intubation

  • 저자

    옥성호

  • 학위수여기관

    慶尙大學校 大學院

  • 학위구분

    국내석사

  • 학과

    의학과

  • 지도교수

  • 발행년도

    2004

  • 총페이지

    vi, 33p.

  • 키워드

    굴곡성 기관지경 심혈관계;

  • 언어

    kor

  • 원문 URL

    http://www.riss.kr/link?id=T10060153&outLink=K  

  • 초록

    BACKGROUND: Endotracheal intubation using fiberoptic bronchoscope causes significant hemodynamic changes such as hypertension and tachycardia. Various drugs including lidocaine, nicardipine, nitroglycerine fentanyl and esmolol have been proposed to attenuate the increased blood pressure and heart rate induced by endotracheal intubation. The aim of this study was to evaluate the effects of alfentanil on cardiovascular response to endotracheal intubation using fiberoptic bronchoscope in the patients anesthetized with N_(2)O-O_(2)-enflurane. METHODS: Forty seven patients (ASA class 1-2) undergoing elective surgery requiring orotracheal intubation were randomly allocated into three groups to get either normal saline (control group), 8 ㎍/kg alfentanil (ALF8 group), or 4 ㎍/kg alfentanil (ALF4 group). Anesthesia was induced thiopental sodium (5 mg/kg) followed by vecuronium (0.1 mg/kg). After induction, study drugs (normal saline, alfentanil) were given intravenously. The lung was ventilated manually for 4 minutes with O_(2) (2 L/min), nitrous oxide (2 L/min) and enflurane (3.5 vol%) via face mask. Orotracheal intubation using fiberoptic bronchoscope was carried out. After orotracheal intubation, the lung was ventilated for 5 minutes with O_(2) (2 L/min), nitrous oxide (2 L/min) and enflurane (2 vol%) via endotracheal tube. Systolic, diastolic, and mean arterial blood pressure, and heart rate were monitored noninvasively and recorded one-minute interval. The time taken for bronchoscopic orotacheal intubation was recorded. Statistical analysis was performed using repeated measures ANOVA followed by Dunnet's test, and Student t test. RESULTS: Mean arterial blood pressure did not alter in the ALF8 group at 1 minute after intubation, but increased (P


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