Association of Alcohol Dependence with Genetic Polymorphisms of Tryptophan Hydroxylase and Serotonin Transporter Regulatory Gene in a Korean Population
Graduate School, Gyeongsang National University
Department of Psychiatry
Alcohol Dependence Tryptophan Hydroxylase Serotonin 정신의학;
- 원문 URL
Objective: In the present study, we investigated the association between alcohol dependence and genetic polymorphisms of tryptophan hydroxylase (TPH) and serotonin transporter regulatory gene (5-HTTLPR) in Korean sample of 75 hospitalized patients with alcohol dependence and 86 normal controls. According to genetic polymorphisms of TPH and 5-HTTLPR, we also investigated the differences of epidemiological and clinical characteristics in patients with alcohol dependence. Method: Seventy-five patients without comorbid disorders were given a diagnosis of alcohol dependence by 2 psychiatrists using DSM-IV criteria and National Council on Alcoholism criteria. We conducted a semi-structured questionnaire inquiring demographic and alcohol drinking-related questions, and clinical assessments using Alcohol Dependence Scale, Beck Depression Inventory, Beck Anxiety Inventory, Barratt Impulsivity Scale, Brief Anger-Aggression Questionnaire, Co-dependency Scale, and Obsessive-Compulsive Drinking Scale. The genotypes of TPH and 5-HTTLPR were determined by using polymerase chain reaction in patients with alcohol dependence and normal controls. Results: Results revealed higher frequency of TPH A allele and A/C genotype in patients with alcohol dependence than in normal controls. But, the frequency of C/C genotype is higher in normal control than in patients with alcohol dependence. We found an excess of TPH C allele in alcoholics with history of depressive mood episode compared with those who have not any depressive episode. And the score of Alcohol Dependence Scale and Impulsivity Questionnaire was significantly higher in alcohol probands with TPH C allele than A allele. But, no association was found between alcohol dependence and genetic polymorphisms of 5-HTTLPR Conclusion: Our results suggest that TPH gene polymorphisms may be a crucial factor in the development of alcohol dependence, but 5-HTTLPR may be not. And a frequency of the TPH C allele is high in Korean male alcohol-dependent patients with history of depressive mood episode, and with more serious manifestations of alcohol dependence and impulsivity.