정신분열병의 발병연령과 할로페리돌 투여전후의 혈장 Catecholamine 대사산물의 농도 변화
Relationship between Age of Onset and Changes of Plasma Catecholamine Metabolites before and after Haloperidol Treatment in Patients with Schizophrenia
정신분열병 발병연령 할로페리돌 혈장 대사산물;
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The author investigated the possibility of homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) concentrations in plasma as biological markers before and after single haloperidol treatment. Sixteen patients with schizophrenia were enrolled after two-weeks washout of neuroleptics. Baseline plasma was obtained at 8:00 AM after washout. After baseline sampling (washout state at 8:00 AM) the patient was treated with haloperidol and consequent sampling was done 24 hours later. The concentrations of HVA and MHPG were compared with age of onset. The HVA and MHPG levels were assayed using high pressure liquid chromatography-electrochemical detection method. The subject were divided into two groups by mean age of onset. A significant association was observed between the age of onset and plasma HVA concentration after haloperidol treatment. The early onset group had lower plasma HVA concentration than the late onset group. More significant association was observed between the age of onset and plasma MHPG concentration after haloperidol treatment. The early onset group had much lower plasma MHPG concentration than the late onset group. These findings suggest that the activities of dopamine and norepinephrine are different with respect to age of onset after haloperidol treatment. Plasma HVA and MHPG concentration can be used as biological markers for subgrouping of schizophrenia. These results might suggest that schizophrenia is not a single disease, but a syndrome. In the near future the author will try to investigate these finding in expanded number of normal controls and patients.