요관류 환자 상극 신장의 조직학적 관찰
Histology of Upper Pole Kidney in Patients with Ureterocele
요관류 신장 조직학;
- 원문 URL
Purpose: I reviewed the histological changes in the upper pole of excised duplex kidneys with ureterocele and assessed the histological variations with respect to age and ureterocele position. Materials and Methods: During the last ten years, 10 patients with duplex system ureterocele underwent upper pole nephrectomy. A total of 10 specimens, of which 4 and 6 diagnosed younger than 1 year old and older than 1 year old, and 5 and 5 involved an intravesical and ectopic location, respectively, were available for independent review by a single pathologist. Histological lesions were classified into the 5 categories of chronic interstitial inflammation, interstitial fibrosis, tubular atrophy, glomerulosclerosis and dysplasia. Each category was divided into moderate/severe histological lesions (greater than 25% involvement) and minimal/mild lesions (25% or less involvement). Results: Chronic interstitial inflammation, interstitial fibrosis, tubular atrophy, glomerulosclerosis and dysplasia in each specimen were graded moderate/severe (greater than 25% involved) in 50%, 50%, 60%, 10% and 80%, respectively. Early detected ureteroceles were not associated with less severe upper pole histological lesions. Also, there were not pathological differences when comparing specimens according to ureterocele position. Conclusions: It appears that the histological lesions observed may be not progressive or reversible. Therefore, I suggest that enhancement of the upper pole renal function does not seem justified in the light of the histological evidence and the goals of clinical management focus on preventing complication and secondary procedure.