흰쥐에서 Nitric Oxide가 자궁 수축에 미치는 영향
Effects of nitric oxide on contractility of the uterine in rats
Nitric Oxide 자궁 수축 골반염증성;
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Nitric oxide (NO) has been found to be of great importance throughout the body as a vasodilator, neurotransmitter and relaxant of vascular and non-vascular smooth muscle. NO is also an important factor in female reproductive processes, including ovulation, menstruation, implantation, pregnancy maintenance, labor and delivery. Recent work suggests that NO may be directly produced from uterine smooth muscle. While the majority of previous studies focused on the possible role of endogenous NO in the maintenance of uterine quiescence during pregnancy, there have been only a few studies on the role for NO in the regulation of non-pregnant uterus. The objective of this study was not only to determine the effect of NO on uterine contractility under normal and inflammatory state in the rat, but to evaluate the role of the second messenger cyclic GMP in NO-modulation of uterine contractility. In addition, this study examined if there are differences in uterine contractility according to estrus cycle state. As results, both the nitric oxide donor sodium nitroprusside (SNP) and endogenous NO reduced spontaneous contractility. Pre-treated with methylene blue(MB, 1mM for 30 min) did not affect the reduction of frequence of uterine contraction induced by SNP injection in both the normal and inflammatory state. These results suggest that both the endogenous and exogenous NO inhibit the spontaneous contractions of the non-pregnant uterus through a cGMP independent pathway in normal and inflammatory uterine tissue.