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체외순환에서 박동혈류와 비박동혈류가 관상동맥 혈류양상에 미치는 영향에 관한 연구 원문보기
(The) Effects of Pulsatile Versus Non-Pulsatile Extracorporeal Circulation on the pattern of Coronary Artery Blood Flow during Cardiac Arrest

  • 저자

    손호성

  • 학위수여기관

    高麗大學校 大學院

  • 학위구분

    국내박사

  • 학과

    의학과

  • 지도교수

  • 발행년도

    2004

  • 총페이지

    51p.

  • 키워드

    체외순환 박동혈류 비박동혈류 관상동맥;

  • 언어

    kor

  • 원문 URL

    http://www.riss.kr/link?id=T10068100&outLink=K  

  • 초록

    In sudden cardiac arrest, the effective maintenance of coronary artery blood flow is of paramount importance for myocardial preservation as well as cardiac recovery and patient survival. An extracorporeal life support system has been applied for its use and non-pulsatile mechanism has been a standard. However, considering the pattern of circulation in the human body, pulsatile extracorporeal circulation may be more physiologic and beneficial in tissue perfusion. The purpose of this study was to directly compare the effects of pulsatile versus non-pulsatile circulation on coronary artery flow and myocardial preservation in a cardiac arrest condition. Methods: A cardiopulmonary bypass circuit was constructed in a ventricular fibrillation model using fourteen Yorkshire swine, weighing 25-35 kg each. The animals were randomly assigned to group I (n=7, non-pulsatile centrifugal pump) or group Ⅱ (n=7, pulsatile T-PLS pump). Extracorporeal circulation was maintained for two hours at a pump flow of 2 L/min. The left anterior descending coronary artery flow was measured with an ultrasonic coronary artery flow measurement system(Quantix/OR^(TM)) at baseline (before bypass) and at every 20 minutes after bypass. The coronary flow was measured three times at each measure, and the median value was selected for analysis. Serologic parameters were collected simultaneously at baseline, 1 hour, and 2 hours after bypass in the systemic arterial and coronary sinus venous blood. The Mann-Whitney U test of STATISTICA 6.0 was used to determine intergroup significances using a p value of


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