정상 임신 기간중 혈중 혈관내피 성장인자 (vascular endothelial growth factor)의 변화 및 혈소판수와의 상관관계
Maternal circulating vascular endothelial growth factor in normal pregnancies and their relationship to platelet counts
정상 임신 혈중 혈관내피 혈소판수;
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Objective: The aim of the present study was to evaluate changes of vascular endothelial growth factor levels in maternal circulating blood during normal pregnancies and examine their relationship with maternal platelet counts. Materials and Methods : The 33 subjects were selected from healthy normotensive women from the antenatal clinic at Korea University Medical Center, Guro Hospital. Blood samples for VEGF were taken at 7 to 8 weeks' gestation, 16 to 18 weeks' gestation, 24 to 26 weeks' gestation, 30 to 32 weeks' gestation, 37 to 41 weeks' gestation. Serum and plasma were extracted from all samples, and VEGF concentrations were measured in duplicates by competitive enzyme immunoassay. The 23 of them, the platelet counts were performed with an automated blood Coulter counter. Results : Serum VEGF levels during normal pregnancies were mean 6.73 ng/ml (95% confidence interval 3.68-9.78 ng/ml) at 7-8 weeks' gestation, 7.88 ng/ml (6.15-9.61 ng/ml) at 16-18 weeks' gestation, 7.18 ng/ml (5.36-9.01 ng/ml) at 24-26 weeks' gestation, 8.42 ng/ml (6.23-10.62 ng/ml) at 30-32 weeks' gestation, 14.03 ng/ml (6.21-21.89 ng/ml) at 37-41 weeks' gestation. Plasma VEGF levels were mean 5.50 ng/ml (3.12-7.87 ng/ml) at 7-8 weeks' gestation, 7.23 ng/ml (5.98-8.47 ng/ml) at 16-18 weeks' gestation, 7.98 ng/ml (4.84-11.11 ng/ml) at 24-26 weeks' gestation, 7.35 ng/ml (5.85-8.84 ng/ml) at 30-32 weeks' gestation, 14.05 ng/ml (6.31-21.79 ng/ml) at 37-41 weeks' gestation. The trends in the mean VEGF levels were similar between serum and plasma, with stable levels until 30 to 32 weeks' gestation, and then the levels were increased. There were no significant difference between serum VEGF levels and plasma VEGF levels (p=0.236) and no correlation between circulating VEGF levels and platelet counts. Conclusion : Maternal VEGF levels during normal pregnancies increased during the last trimester. Our data suggest that platelets may not be the origin of elevated VEGF levels in normal pregnancies because there were no correlation between VEGF levels and platelet counts. The larger study are needed to determining the source of VEGF production in pregnancy.