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근적외 분광분석법을 이용한 피부 수분정량 모델의 개발 및 적용 원문보기
Development and Application of Quantitative Model for Skin Moisture using Near Infrared Spectroscopy

  • 저자

    서은정

  • 학위수여기관

    同德女子大學校 大學院

  • 학위구분

    국내석사

  • 학과

    약학과 약학전공

  • 지도교수

  • 발행년도

    2003

  • 총페이지

    vi, 55p.

  • 키워드

    근적외 분광분석법 피부 수분정량 모델;

  • 언어

    kor

  • 원문 URL

    http://www.riss.kr/link?id=T10070259&outLink=K  

  • 초록

    Skin covers the entire body and protects it from various types of external stimuli and damage as well as from moisture loss. Especially, the main role of water in the outermost layer of skin, the stratum corneum (SC), is to control softness and pliability. Changes in the water content of the SC have important consequences for the functional properties of human skin. Therefore, it is very important to maintain sufficient moisture in the SC for healthy skin. In this study, the rapid and nondestructive method for determination of the water content in SC was developed. A portable NIR system, a FT NIR spectrometer, and a fiber optic probe were used to acquire NIR diffuse reflectance spectra of hairless mouse skin. In the near infrared, water molecules show two clear absorption bands at 1450 nm from first overtone of O-H stretching and 1940 nm from the combination involving O-H stretching and O-H deformation. It was found that the variations of O-H absorption band according to water content. Partial least squares regression (PLSR) was applied to develop a calibration model. The PLS model showed a good correlation between NIR predicted value and the absolute water content of separated hairless mouse skin, in vitro. Also routine analyses were performed during 3 days. The NIR routine analyses results showed a similar tendency with the absolute water content of separated hairless mouse skin, in vitro. We acquired human skin spectra using a portable NIR system covering longer wavelength regions from 1100 to 2200 nm at before and 3 hours after treatment of moisturizer. For practical use for the evaluation of human skin moisture, the PLS model for human skin moisture was developed in vivo, on the basis of the relative water content values of SC from the conventional capacitance method. The calibration model predicted human skin moisture with a standard errors of prediction (SEP) of 4.35 at 1150∼1700 nm range. In order to validate the developed calibration model and estimate the effect of moisturizer, routine analyses were performed at 3 days and 1, 2, 4 weeks after treatment of moisturizer. The NIR routine analyses results showed a similar tendency with the conventional capacitance method. These studies showed the possibility of a rapid and nondestructive skin moisture measurement using NIR spectroscopy. It can be used for measurement of human skin and estimation of moisturizer effect.


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