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가와사끼병 환아에게서 회복 2개월 후 비타민 C 농도 변화 원문보기
Change of Vitamin C Concentration 2 Months after Recovery in Kawasaki Disease

  • 저자

    최희라

  • 학위수여기관

    慶尙大學校 大學院

  • 학위구분

    국내석사

  • 학과

    의학과

  • 지도교수

  • 발행년도

    2004

  • 총페이지

    vi, 26p.

  • 키워드

    가와사끼병 비타민C 의학;

  • 언어

    kor

  • 원문 URL

    http://www.riss.kr/link?id=T10079884&outLink=K  

  • 초록

    Kawasaki disease is an acute febrile vasculitis. Since it was first described in the Japanese literature in 1967, Kawasaki disease has been reported worldwide. Despite many research, the etiology of Kawasaki disease is currently unknown. The majority of the morbidity and mortality associated with this disease is attributable to the development of coronary artery aneurysm. This condition is found in approximately 10-20% of children with Kawasaki disease and has been reported to result from overproduction of reactive oxygen species by neutrophils during the early stage of the disease. On the other hand, a self-defense system exists against oxidative injuries; high molecular weight antioxidant such as SOD, catalase, glutathione peroxidase and low molecular weight antioxidants such as vitamin C, E, A, polyphenols, flavonoids, and catechin. Vitamin C among antioxidant in human is a physiological antioxidant for protection against diseases and degenerative process caused by oxidant stress. At present, it is not enough research for vitamin C as antioxidant. The aim of this study is to compare of vitamin C concentration between acute and convalescent phase in Kawasaki disease in order to know the correlation of vitamin C and Kawasaki disease. In addition, we investigated change of vitamin C concentration according to ingestion of vitamin C in convalescent phase. The venous blood at 25 cases of Kawasaki disease were collected from June 2001 to August 2003 at Gyeongsang National University Hospital. Concentrations of vitamin C in whole blood and plasma were measured by the 2,4-dinitrophenylhydrazine method. Concentration of vitamin C concentration of blood cell was calculated by formula in previous study. The results were summarized as follows; Concentrations of vitamin C at acute and convalescent phase in whole blood were 1.56 mg/dL(median) and 1.78 mg/dL(median), respectively. Concentrations of vitamin C at acute and convalescent phase in plasma were 0.73 mg/dL(median) and 0.99 mg/dL(median), respectively. Concentrations of vitamin C at acute and convalescent phase in blood cell were 2.85mg/dL(median) and 3.60 mg/dL(median), respectively. The change of vitamin C concentration in whole blood and plasma were significant correlation of statistical evaluation(P


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