정신분열병 환자에서 Risperidone과 Olanzapine의 치료 효과와 부작용의 비교
Comparison of Therapeutic and Adverse Effects of Risperidone and Olanzapine in Schizophrenic Patients
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Risperidone and olanzapine, which are atypical antipsychotics, are widely used in the treatment of schizophrenia, improving positive and negative symptoms. However, they show differences with the chemical structure and pharmacokinetics, and they work differently to receptors. The author studied the comparative effects on therapeutic efficacy, serum glucose, cholesterol and prolactine levels and adverse effects of risperidone and olanzapine as an open prospective study. Sixty subjects with DSM-IV schizophrenia were assigned to receive risperidone or olanzapine for 12 weeks. Psychopathology, adverse effects, weight change, fasting serum glucose, cholesterol and prolactin were compared within and across groups. Twelve weeks later, both treatment groups showed significant improvement in PANSS positive, negative, general and total scores, while they did not show any significant difference between two groups. In terms of adverse effects, risperidone group showed more extrapyramidal symptom than olanzapine group. Body weight increased significantly after 12 weeks in olanzapine group, but there was no significant difference between two treatment groups. There were no significant increase in fasting serum glucose level. These results suggest that both risperidone and olanzapine are effective drugs which can be used during the acute phase of schizophrenia. However, olanzapine had an advantage with less neurologic side effect than risperidone.