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자동차 배기가스 검사원과 소각장 근로자에서의 유전, 면역, 생식독성 및 Gluthathione S-transferase M1,P1,T1과 CYP1A1 유전적 다양성이 유전독성에 미치는 영향 원문보기
Genetoxic, Immunotoxic and reproductive toxic evaluations and the correlation between genetic polymorphism for gluthatione S-transferase M1, P1 and T1 and CYP1A1 and DNA damages in automobile emission inspectors and incineration workers

  • 저자

    오은하

  • 학위수여기관

    高麗大學校 大學院

  • 학위구분

    국내박사

  • 학과

    보건학협동과정

  • 지도교수

  • 발행년도

    2004

  • 총페이지

    vii, 75p.

  • 키워드

    자동차 배기가스 검사원 소각장 근로자 유전독성;

  • 언어

    kor

  • 원문 URL

    http://www.riss.kr/link?id=T10082005&outLink=K  

  • 초록

    Occupational exposure to polycyclic aromatic hydrocarbons(PAHs) increases the risk of developing cancer. Human exposure to PAHs has been evaluated using biological monitoring markers such as the level of inhaled PAHs, the level of urinary methabolites including 1-OHP and 2-naphthol and the level of DNA damage. Individual susceptability to PAHs has been also measured by DNA polymorphims of several related genes. Objectives : This study aimed to evaluate the effects of PAHs on genotoxicity, immunotoxicity and reproductive toxicity and to determine to correlation between genetic polymorphism for glutathion S-transferase M1, T1 and P1 and CYP1A1 DNA damages in automobile emission inspectors and incineration workers. Methods : The level of inhaled PAHs and the level of 1-hydroxypyrene(1-OHP)and 2-naphthol in urine in workers and control subjects were analyzed by GC and HPLC. The DNA damage was determined using comet assay in lymphocyte, T-cell, B-cell, Granulocyte. Immunotoxicity measurement was performed by ELISA using monoclonal antibodies. Results : Occupational exoposure to PAH resulted in statistically significant increased 1-OHP and 2-naphthol levels(p


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