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유방암종에서 KAI-1과 survivin의 발현에 대한 연구 : Expression of KAI-1 and Survivin in infiltrating Ductal Carcinoma of Breast 원문보기

  • 저자

    손병호

  • 학위수여기관

    고려대학교 대학원

  • 학위구분

    국내박사

  • 학과

    의학과

  • 지도교수

  • 발행년도

    2004

  • 총페이지

    xixp.

  • 키워드

    유방암종 KAI-1 survivin;

  • 언어

    eng

  • 원문 URL

    http://www.riss.kr/link?id=T10082022&outLink=K  

  • 초록

    Objective To investigate KAI1 and survivin expession in infiltrating ductal carcinomas, and to evaluate the relationship between the clinicopathological factors and KAI1 and survivin expression in breast cancers. Materials and Methods The KAI1 and survivin expression from 62 patients were measured using immunohistochemical staining. Western blot analysis was performed on eight cases. The DNA ploidy was determined by flow cytometry. Results The results of the KAI1 expression were as follows: 14 cases(21.0%) were preserved(++), 25(40.3%) were reduced(+), and 24(38.7%) were loss(-). The survivin expression were as follows: 6 cases(9.7%) were strong positive(++), 28(45.15%) were positive(+), and 28(45.15%) were negative. The survivin(p=0.0009) and KAI1(p=0.0091) expressions correlated with the survival rate. However, there was no significant difference between the survivin and KAI1 expressions and the clinicopathological factors. Three different groups according to survivin and KAI1 co-expression levels correlated with the clinical stage and the survival rate. The DNA ploidy did not correlate with the survivin and KAI1 expression levels and the survival rate. Conclusions KAI1 and survivin expression levels might be prognostic factors in breast cancers.


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