Design & Implementation of 1D MPI Based Hybrid System for Monitoring of Magnetic Nanoparticles for Targeted Drug Delivery
Magnetic Particle Imaging Nano Particles Magnetic Actuation Drug Delivery System;
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Targeted drug delivery using magnetic nanoparticles (MNPs) is an efficient technique to deliver drug molecules to specific tissues in a human body. An electromagnetic actuation system is a promising solution for applying an adequate force to steer the MNPs in the blood vessels in a non-invasive way. In this paper, a combined actuation and monitoring system is proposed to provide a closed-loop nanoparticle localization of the MNPs based on magnetic particle imaging (MPI) for more precise targeting. The MNPs can be steered by applying a magnetic field gradient provided by the actuation system and monitored by applying the drive and selection fields to the actuation coils using a time division multiplexing scheme. The aim of this research is mainly to investigate the feasibility of combining the actuation system with a MPI system using numerical simulations and optimizing hardware constraints. The challenge in this research is to sequence the actuation signal and the MPI signal to perform both tasks simultaneously. The COMSOL Multiphysics software is used for modeling and simulation of the proposed system. The simulation results showed the feasibility of the MPI based actuation system. Numerical and parametric simulations of the 1D systems are done in COMSOL Multiphysics software. The proposed 1D system is implemented and an experimental study of magnetic field strengths and workspace size is given in this thesis. A comparison of simulation and experimental results is also proposed and presented. The proposed system will provide simultaneous navigation and tracking for targeted drug delivery of magnetic nanoparticles in compact and efficient ways.