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Protective effect of Quercus salicina Blume Extract in Calcium Oxalate Urolithiasis Model and Arthritis Model

  • 저자

    정명희

  • 학위수여기관

    경성대학교 일반대학원

  • 학위구분

    국내박사

  • 학과

    약학과 생명약학

  • 지도교수

    최종원

  • 발행년도

    2014

  • 총페이지

    83 page

  • 키워드

    Quercus salicina Blume calcium oxalate urolithiasis model renal oxidative stress marker arthritis model rheumatoid factor;

  • 언어

    kor

  • 원문 URL

    http://www.riss.kr/link?id=T13535281&outLink=K  

  • 초록

    Quercus species have been used for diarrhea, dysentery, dermatitis, and hemorrhagia in Korean folk medicine. Specially Quercus salicina Blume which is distributed through the southern parts of the Korean Penisula and Japan, has been used for diuretic, anti-inflammatory antiedemic and litholutic agent. Many coumpounds such as stenophyllanin a, b, c, salidroside gallate, scyllo quercitol galltem quinic acid gallate, stenophynin A, B, grandinin, acuttissimin A, G, guaiacyl glycerol are reported form Quercus salicina Blume. Kidney stones occur in approximately 1% of the population during their lifetime. Although the development of extracorporeal shock wave lithotripsy (SWL) has revolutionized the theraphy of urolithiasis, the rate of recurrence of urothiasis, the rate of recurrenece of stones after SWL is about 50% within 10 years, which still represents serious problems for patients. So to clarify the mechanism of Urocalum, and QS (Quercus salicina Blume) extract in the treatment of urolithiasis. Rat calcium oxalate urolithiasis was induced by oral administration of ethylene glycol and the vitamin D3 analog alfacalcidol for 14 days and QS extract was given to rats. After the last administration, we measured in urine, serum and renal oxidative stress marker. Ethylene glycol and alfacalcidol treatment increased BUN, creatinine, uric acid and XO. This increase was significantly suppressed by the administration of QS extract. These finding suggest that the QS extract plays a role in the prevention of stone formation and recureence in urolithiasis. And we evaluated effective on the progression of arthritis, using FCA induced arthritic rats. Not significantly change of body weight, organ weight and lethal dose effect according to the period of Quercus salicina Blume water extract. And hematoxylin and eosin staining showed that the QS leaf water extract reduced the infiltration of inflammatory cells and prevented joint destruction of the knee and paw. QS extract treatment also decreased the production of rheumatoid factors (RF) in the serum of FCA- induced rats. In analgesic effects by the acetic acid writhing method and hot plate method were significantly effective in all sample groups and pretreatment of extract. The RF concentration it showed a positive responese in control and treatment of water extract, was decreased a positive response.


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