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Dietary nitrate 섭취가 유산소운동 시 심혈관 반응에 미치는 영향 원문보기

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    본 연구의 목적은 비트루트 쥬스 섭취를 통하여 증가된 혈중 NOx 농도가 강도별 유산소운동 시 심혈관 반응에 미치는 영향을 검토하고, 감소된 혈압 반응에 대한 생리학적 기전을 규명하는 것이다. G도 K대학교에 재학 중인 20세 이상의 남자 대학생 12명으로 SBP 120 mmHg, DBP 80 mmHg 이하인 정상혈압자이며, 최근 6개월 이내에 규칙적이고 체계적인 트레이닝에 참여한 경험이 없는 자, 혈압 약물을 복용하지 않으며 심폐질환이나 정형외과적 질환이 없는 자발적인 참여자들로 선정하여 이중맹검교차법(double blind and cross over)에 따라 비트루트 쥬스 처치 실험과 위약 처치 실험에 반복하여 참여하였다. 16일간 비트루트 쥬스를 섭취 시킨 후, 안정 시 와 운동 시 심혈관 반응에 미치는 영향을 검토한 결과 비트루트 쥬스 섭취 후 안정 시와 30% 운동강도에서 CO가 유의하게 증가하였다(p


    It was recently reported that dietary nitrate supplementation(NS) via beetroot juice(BJ) decreased blood pressure and oxygen consumption during exercise. Despite these observations, the effects of NS on cardiovascular responses during dynamic exercise have not been investigated in humans. It was to investigate the roles of cardiac output(CO) and peripheral vasoconstriction in eliciting the blood pressure response to NS at rest and during cycling exercise ranging from mild to heavy workloads (30%, 60%, and 80% of O2max) in healthy persons. In a double-blind randomized crossover study, 12 subjects, aged 21∼25 yrs, supplemented their diet for 16 days with either high-rich concentrated BJ(70ml/day, 0.4mg/day NO3-) or a nitrate-depleted BJ placebo(70ml/day, 0mg/day NO3-). The subjects were continuously instrumented to measure CO and mean arterial blood pressure(MAP), and the responses to graded exercise were observed before and after BJ and placebo(PL) in the same subjects. After intaking BJ, plasma nitrate concentration was significantly higher at rest and during exercise compared to the PL. NS significantly decreased total vascular conductances(TVC, calculated as CO/MAP) and MAP at rest and these differences continued during dynamic exercise. There were no differences CO responses in before and after BJ and PL. NS alters the cardiovascular responses at rest and dynamic exercise and as workload increased, more dilation occurred in peripheral vasculature causing less increases in MAP. These results suggest that NS may enhance vasoprotection and prevent an exaggerated blood pressure response during exercise in humans.


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