Evaluation of MPTP-induced Parkinson's disease in the Cynomolgous Monkey
- 원문 URL
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. In the United States, approximately 1 million people manage PD and in Europe it is estimated prevalence of 1 to 2% in the population over 65 years of age. Pathological feature of PD is degeneration of dopaminergic neurons in the substantia nigra pars compacta, but the specific etiology of PD is not known. Epidemiologic studies indicate that a number of factors may increase the risk of PD. Hence, the present study assessed in vivo anatomical and functional changes in brain using the PET and MRI and evaluated the monkey model after MPTP administration. To this end, established MPTP-induced PD model of cynomolgus monkeys and measured in same subjects the progressive degeneration of dopaminergic cells by neuroimaging and behavioral test. The body weight and behavioral response decreased over time and maintained later. Binding potential (BP) of [11C]Raclopride increased, both BP of [18F]Fallypride and [18F]FP-CIT decreased. In the MRI, enlargement of the lateral ventricle in the brain was confirmed. These results showed that the advanced imaging (PET and MRI) can be fully evaluated the MPTP-induced PD model and presented evaluation criteria for monkey model, thereby expect to greatly contribute early diagnosis and therapy in PD.