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High-sensitive cardiac troponin I in Korean chronic kidney disease patients without acute cardiovascular disease: Reference interval, relationship with disease severity, and prognostic impact for cardiovascular complication 원문보기

  • 저자

    박미정

  • 학위수여기관

    가천대학교 대학원

  • 학위구분

    국내박사

  • 학과

    진단검사의학

  • 지도교수

    박필환

  • 발행년도

    2014

  • 총페이지

    35 p.

  • 키워드

    high-sensitive cardiac troponin I chronic kidney disease cardiovascular complication;

  • 언어

    eng

  • 원문 URL

    http://www.riss.kr/link?id=T13537381&outLink=K  

  • 초록

    Background: Patients with chronic kidney disease (CKD) have higher cardiovascular morbidity and mortality. High-sensitive cardiac troponin I (hsTnI) may contribute to the risk stratification of patients with CKD for cardiovascular events and survival. We investigated the cut-off level of hsTnI (99th percentile of the reference population), relationship between hsTnI and renal function markers, and prognostic value of elevated hsTnI for CVD morbidity in CKD patients. Methods: We enrolled 120 CKD patients and 276 normal reference individuals. Serum hsTnI was measured by using the commercial ARCHITECT STAT High-Sensitive Troponin Assay. Serum cystatin C and creatinine were measured by the modified Jaffe method and enzyme method. Clinical data about cardiovascular history, lipid profile, body mass index, and prognosis were collected by review of medical records. Results: With the exception of 2 outliers (one in female and one in male), the cut-off of hsTnI (99th percentile value) in the reference population was 14.6 pg/ml in female and 18.1 pg/ml in male. The hsTnI was significantly higher in CKD patients than the reference population (p


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