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MPTP로 유발한 파킨슨병 생쥐 모델에서의 운동 효과 검증 : Effects of treadmill exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine lesioned mouse model 원문보기

  • 저자

    백미나

  • 학위수여기관

    가천대학교 대학원

  • 학위구분

    국내박사

  • 학과

    의과학

  • 지도교수

    조장희

  • 발행년도

    2014

  • 총페이지

    47 p.

  • 키워드

    Parkinson's disease 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine (MPTP) Treadmill exercise Behavioral test microPET [18F] Fallypride;

  • 언어

    eng

  • 원문 URL

    http://www.riss.kr/link?id=T13537384&outLink=K  

  • 초록

    Parkinson's disease (PD) is a progressive neurodegenerative disease accompanied by motor dysfunctions. Exercise leads to promote neuroplasticity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD. We evaluated the MPTP lesioned mouse models and investigated the effect of treadmill exercise using several motor behavioral tests and microPET scan. C57BL/6 mice were divided into four groups: (1) Saline, (2) Saline+Exercise (Saline+Ex), (3) MPTP, and (4) MPTP+Exercise (MPTP+Ex). Mice were pre-trained on rotarod prior to MPTP lesioning. At 5 days after MPTP lesioning, mice were tested rotarod to evaluate the MPTP lesioned models. And then exercise was initiated 5 days after MPTP lesioning and continued for 6 weeks. After the 5 days of MPTP lesioning, MPTP treated mice were significantly reduced the rotarod performance. At the end of 6 weeks exercise, exercised group showed significantly increased rotarod performance compared to non-exercise mice. Other motor behavioral tests including wire hanging test, vertical grid test and gait test have been shown significant results in exercised mice. Also, exercise led to change the DA-D2R expression. In saline group, exercised group showed significantly increased DA-D2R binding potential (BP). By contrast, exercised MPTP group mice showed different results. In the present study, we demonstrated that exercise improves motor function in MPTP lesioned mouse.


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