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초고자장 자기공명영상 연구에서 지연회상과 해마이행부의 T2* 이완시간 관계연구 : Association between delayed recall and T2* relaxtion time of the subiculum: Implications of ultra-high field magnetic resonance imaging 원문보기

  • 저자

    황석일

  • 학위수여기관

    가천대학교 일반대학원

  • 학위구분

    국내박사

  • 학과

    의과학

  • 지도교수

    조장희

  • 발행년도

    2014

  • 총페이지

    43 p.

  • 키워드

    Ultra-high-field Hippocampus Subiculum Adolescent;

  • 언어

    eng

  • 원문 URL

    http://www.riss.kr/link?id=T13537425&outLink=K  

  • 초록

    A number of evidences suggest that hippocampus involve in the memory function. The most prevailing view is that hippocampus plays a key role especially for long-term memory, although recent studies have reported that hippocampus is also important for the short-term memory including visuospatial information (Finke et al, 2008). As hippocampal complex is composed of different subregions, animal studies have suggested different roles of each hippocampal subregions in memory functions (Deadwyler et al, 2006). One subregion of hippocampus may play a predominant role for one type of memory function, while different subregion may be more responsible for another type of memory function. However, in human, it has not been clearly demonstrated which subregion of hippocampus is more involved in specific memory function. One plausible reason may lie in the fact that investigating the total hippocampus using conventional resolutions of prior imaging studies had inevitable limitations in detecting changes of hippocampal subregions. Recently, ultra-high-field (UHF) MRI systems have become available for in-vivo human research. The UHF MRI such as 7.0T enables providing substantially improved images in resolution and contrast (Li et al., 2006; Duyn et al., 2007; Cho et al., 2009). Especially, T2* contrast at UHF has reveal a number of brain structures which were not visible in 1.5 T or 3.0 T MR images (Li et al., 2006; Duyn et al., 2007). The hippocampal boundaries are well-demarcated in UHF T2* contrast images clearly-demonstrating hippocampal subregions (Cho et al., 2009). In addition to the contrast, T2* relaxometry with UHF MRI may be more sensitive in the detection of abnormalities compared to T2*-weighted image obtained utilizing conventional scanners. T2 or T2* relaxometry may measure tissue composition. T2* images commonly represent the water content of tissue. T2 or T2* relaxation time (T2*-RT) also correlates with iron content (Gelman et al., 1999) or steady-state regional blood volume (Anderson et al., 2005) of the tissue. Therefore, T2 or T2* relaxation time may correlate with resting neuronal activity (Teicher et al., 2000) or micro-damage of brain tissue (Cross et al., 2008). Only one study using 1.5 T MR has reported the association between T2-RT of subiculum and long-term memory (Small et al, 2000). However, the neuropsychological correlates of hippocampal T2*-RT has not been investigated with UHF MRI, in spite of its higher sensitivity in detecting the change of signal intensity (Schenck et al., 2004).


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