본문 바로가기
HOME> 논문 > 논문 검색상세

학위논문 상세정보

자궁경부의 상피내암과 초기 침윤성 편평상피 암종의 조직학적 소견의 차이 원문보기
Differential histologic features between preinvasive and early invasive squamous cell carcinoma of uterine cervix; their diagnostic utility for recognition of early stromal invasion

  • 저자

    손은미

  • 학위수여기관

    울산대학교

  • 학위구분

    국내석사

  • 학과

    의학과 병리학

  • 지도교수

    김규래

  • 발행년도

    2014

  • 총페이지

    19

  • 키워드

    : squamous cell carcinoma cervical carcinoma uterine cervix stromal invasion angiogenesis;

  • 언어

    kor

  • 원문 URL

    http://www.riss.kr/link?id=T13540443&outLink=K  

  • 초록

    Background: Early invasive squamous cell carcinomas of the cervix can be easily missed on colposcopic and histologic examination. Moreover, histological determination of early stromal invasion is at times very difficult, especially in small biopsy specimens. Aim: Although several histologic features have been proposed as the evidence of stromal invasion, none of the features was verified. To find helpful histologic features for the recognition of early stromal invasion in squamous cell carcinoma of uterine cervix, we compared the incidences of various histopathologic findings in the unequivocal cases of HSIL and invasive squamous cell carcinomas of the uterine cervix. In addition, density of newly formed blood vessels defined by endoglin immunopositivity, and the vascular pattern such as coated and uncoated blood vessels, and complete and incomplete blood vessels were compared between the two groups. Methods: Unequivocal cases of 112 invasive squamous cell carcinomas (SCC) and 26 high grade squamous intraepithelial lesion (HSIL) diagnosed on the hysterectomy specimens were retrieved, and six histopathological parameters were compared, which include (1) presence of desmoplastic change, (2) presence of irregular epithelial tongues of malignant cells, (3) focal squamous differentiation with eosinophilic cytoplasm, (4) blurring of interface by lymphoplasma cell infiltration, (5) pseudoglands with central necrosis, (6) Scalloped contours of malignant epithelial nests and (7) random axis of rete pegs. In addition, microvascular density and vascular pattern and newly formed blood vessels using endoglin (CD105) immunostaining were compared in 17 cases of HSIL and 27 cases of invasive SCC. Results: Histologic findings of (1) presence of desmoplastic change (p


 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역