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Thin, Flexible and Implantable Capacitive Microelectrode for in vivo Biopotential Recording 원문보기

  • 저자

    변항진

  • 학위수여기관

    고려대학교 대학원

  • 학위구분

    국내석사

  • 학과

    바이오융합공학과

  • 지도교수

    이상훈

  • 발행년도

    2014

  • 총페이지

    56 p.

  • 키워드

    Biopotential Recording ECG Capacitive Recording;

  • 언어

    eng

  • 원문 URL

    http://www.riss.kr/link?id=T13541945&outLink=K  

  • 초록

    We developed a new thin and flexible capacitive microelectrode that may be implanted into the body of a subject for the purpose of biopotential recording without permitting direct contact between the metal layer of electrode and surrounding tissue which may induce damages on the tissue electrically and/or biologically. The fabricated metal based electrode was fully encapsulated in polydimethylsiloxane (PDMS), which is non-conductive and highly biocompatible. The electrode's performance in acquiring physiological signals was evaluated by implanting the device subcutaneously on the back of a rat. Three electrodes of different sizes were tested, and the signal was found to be enhanced in proportion to the size of the recording site area and the electrocardiogram (ECG) were found to increase in strength over the observation period. The PDMS layer acted as a protection layer, and no metal damage was observed after implantation. We successfully recorded ECG signals over 4 weeks without observing signal distortions or attenuation. The equivalent circuit was calculated by measuring impedance of electrode in a pH 7.4 PBS solution until no significant changes were observed. The result showed that the capacitance played pivotal role in sensing signal, even after the PDMS had fully absorbed the PBS buffer. To ensure electrical safety under in vivo conditions, the leakage current was measured. More than 99% of the current was prevented from leakage into the surrounding tissue, in contrast with the current leaked by direct-contact electrodes. No inflammation was observed during the in vivo biocompatibility tests because the metal did not directly contact the tissue.


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