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간세포암종의 잔존 간기능, 병기, 치료방법에 따른 예후 및 modified UICC, BCLC, CLIP, CUPI, JIS 및 Tokyo 병기 체계들의 예후 분별력 비교 : 단일 기관 코호트 원문보기

  • 저자

    제지혜

  • 학위수여기관

    고려대학교 대학원

  • 학위구분

    국내석사

  • 학과

    의학과 내과학전공

  • 지도교수

    변관수

  • 발행년도

    2014

  • 총페이지

    41 p.

  • 키워드

    Hepatocellular carcinoma Survival Staging systems;

  • 언어

    kor

  • 원문 URL

    http://www.riss.kr/link?id=T13541999&outLink=K  

  • 초록

    Background: Hepatocellular carcinoma (HCC) is one of the most common cancer and has poor prognosis. Several staging systems for HCC have been proposed but there is no worldwide consensus which staging system is optimal. We analyzed survival in patients with HCC according to liver function, current staging systems and modality of treatment and identified the best staging system for predicting outcome in patients with HCC in Korea Methods: Between January 2004 and December 2009, 875 HCC patients who were newly diagnosed and treated at the Korea University Guro hospital were enrolled. They were followed up till April 2014. All patients were classified by modified UICC, Barcelona-Clinic Liver Cancer (BCLC), Cancer of the Liver Italian Program (CLIP), Chinese University Prognostic Index (CUPI), Japan Integrated Staging (JIS), Tokyo score. The demographic data, clinical variables, tumor characters, residual liver function and initial treatment modalities were reviewed. We performed survival analysis using Kaplan - Meier method and Cox regression. The discriminatory ability of staging system was quantified using concordance index (C-index). The homogeneity and monotonicity of staging system was assessed using likelihood ratio χ2 test correlated with a Cox's regression model neutralized by Akaike information criterion (AIC). Results: 654 (74.7%) patients died and the median survival time was 25 ± 1.5 months. The 5-years survival was 28.1%. The 5-years survival were as follows, 37.7%, 11.4% and 8% (p


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