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우리나라 유행성뇌염(流行性腦炎)의 역학적(疫學的) 및 혈청학적(血淸學的) 조사연구(調査硏究)
Epidemiological and Serological Investigation on Epidemic Encephalitis in Korea

이주원   (서울대학교 의과대학 예방의학교실UU0000691  ); 김경호   (서울대학교 의과대학 예방의학교실UU0000691  ); 김인달   (서울대학교 의과대학 예방의학교실UU0000691  );
  • 초록

    The author has investigated epidemiological features of human cases of epidemic encephalitis (E. E.) in the Republic of Korea and the status of antibody requisition in pre-and post-epidemic time. And virological and serological studies with regarding the relationship of E. E. infection between human and piglet, and field survey against its vector by means of virus isolation from mosquitoes were carried out. Finally, vaccine field trial against human population has also been evaluated in order to confirm its effectiveness. The results of the studies are summarized as follows : 1. The annual incidence of reported cases during the past 25 years (1949-1973) in the Republic of Korea has shown two patterns, one was typical cyclic incidence and the other one was irregular. Annual average morbidity and mortality rate per 100,000 population were 5.7 and 2.1 and fatality rate was 34.6% in typical cyclic years. 2. With regard to the geographical distribution of E. E., the province of Jeolla-Bug-Do illustrated the highest incidence regardless of the epidemic size. 3. The main epidemic period was between mid-August and mid-September (above 90% of the total number of cases). The first case was reported in middle of July and the epidemic ceased in late of October. 4. An analysis of the age distribution of cases of E. E., has shown that above 90% of the total cases occurred in the age groups under 14 years and it was noted that about its 54% were occurred in the age groups between 5-9 years group. 5. Through the Haemagglutination Inhibition (H-I) test for the laboratory diagnosis of E. E., it was found that higher H-I antibody titer was usually detected in the convalescent phase, 15 days after onset. 6. The H-I antibody survey against 563 healthy population by age groups during the pre-epidemic season showed that 422(75%) were less than H-I titer, 1:20 and 122(21.7%) were positive H-I titer, 1:20. Among the 94 American in Seoul who had not been in E. E. endemic area previously only one person had appeared sero-conversion as a H-I titer of 1:80 after post-epidemic season. 7. The E. E. virus could be isolated from the mosquitos pools-C, tritaeniorhyncus which were caught between late July and middle August. 8. E.E. Virus was also isolated from piglet blood on early August and H-I antibody conversion was occurred mostly on middle of August. 9. H-I antibody sero-conversion rate reached to high level when vaccine purified by mouse brain tissue inoculated, showing 98.9%. Higher antibody titer was acquired when booster inoculation was performed, Four fold rise of H-I add N-T antibodies was confirmed with 93.2% and 82.1% respectively.


 저자의 다른 논문

  • 김인달 (4)

    1. 1970 "한국 영유아기에 있어서의 이유 양상과 영양상태에 관한 연구" 韓國營養學會誌 = The Korean journal of nutrition. 3 (2): 65~80    
    2. 1972 "연탄(煉炭)가스 중독자(中毒者)의 생활환경(生活環境)에 관(關)한 역학적(疫學的) 연구(硏究)" 예방의학회지 = Korean journal of preventive medicine 5 (1): 9~15    
    3. 1974 "급성일산화탄소중독치료(急性一酸化炭素中毒治療)에 관(關)한 역학적(疫學的) 연구(硏究) -서울대학교(大學校) 의과대학(醫科大學) 부속병원(附屬病院) 고압산소치료실(高壓酸素治療室)의 환자(患者)를 중심(中心)으로-" 예방의학회지 = Korean journal of preventive medicine 7 (2): 359~366    
    4. 1974 "한국인혈압(韓國人血壓)의 정상치역(正常値域)" 예방의학회지 = Korean journal of preventive medicine 7 (2): 395~401    

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