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Bioconversion of Aniline to Acetaminophen and Overproduction of Acetaminophen by Streptomyces spp.

Jin, Hyung-Jong   (College of Pharmacy, Seoul National University  ); Park, Ae-Kyung   (College of Pharmacy, Seoul National University  ); Lee, Sang-Sup   (College of Pharmacy, Seoul National University  );
  • 초록

    In order to obtain acetaminophen, a popular analgesic-antipyretic, though microbial p-hydroxylation and N-acetylation of aniline, various Streptomyces strains were screened. Aniline N-acetylation activity was rather ubiquitous but-hydroxylation activity was selective. Microbial conversion pathway of aniline to acetaminophen was considered to be through N-acetylation and p-hydroxylation or vice versa. However, depending on species used, o-hydroxylation and its degradation activity (S. fradiae) and acetaminophen degradation activity (S. coelicolar) were also detected. Among the screened Streptomyces strains, S fradiae NRRL 2702 showed the highest acetanilide p-hydroxylation activity (203% conversion rate). Furthermore, in S. fradiae carbon source and its concentration, phosphate ion concentration and pH of growth medium were found to play the crucial roles in p-hydroxylation activity. Through the proper combination of factors mentioned above, the ten times more activity (26-30% conversion rate) was attained.


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  • 주제어

    Aniline  . acetaminophen  . hydroxylation  . Streptomyces fradiae  . acetaminophen degradation activity  . meium component effect  . high production  .

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