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Bioconversion of Aniline to Acetaminophen and Overproduction of Acetaminophen by Streptomyces spp.

Jin, Hyung-Jong    (College of Pharmacy, Seoul National University   ); Park, Ae-Kyung    (College of Pharmacy, Seoul National University   ); Lee, Sang-Sup    (College of Pharmacy, Seoul National University  );
  • 초록

    In order to obtain acetaminophen, a popular analgesic-antipyretic, though microbial p-hydroxylation and N-acetylation of aniline, various Streptomyces strains were screened. Aniline N-acetylation activity was rather ubiquitous but-hydroxylation activity was selective. Microbial conversion pathway of aniline to acetaminophen was considered to be through N-acetylation and p-hydroxylation or vice versa. However, depending on species used, o-hydroxylation and its degradation activity (S. fradiae) and acetaminophen degradation activity (S. coelicolar) were also detected. Among the screened Streptomyces strains, S fradiae NRRL 2702 showed the highest acetanilide p-hydroxylation activity (203% conversion rate). Furthermore, in S. fradiae carbon source and its concentration, phosphate ion concentration and pH of growth medium were found to play the crucial roles in p-hydroxylation activity. Through the proper combination of factors mentioned above, the ten times more activity (26-30% conversion rate) was attained.


  • 주제어

    Aniline .   acetaminophen .   hydroxylation .   Streptomyces fradiae .   acetaminophen degradation activity .   meium component effect .   high production.  

 저자의 다른 논문

  • 박애경 (5)

    1. 1992 "Genetic Analysis on Bioconversion of Aniline to Acetaminophen in Streptomyces fradiae" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 15 (1): 35~40    
    2. 1992 "Enzymatic Study on Acetanilide p-Hydroxylase in Streptomyces fradiae" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 15 (3): 215~219    
    3. 2007 "유전체 연관 연구에서의 검정력 및 연구대상수 계산 고찰" Journal of preventive medicine and public health = 예방의학회지 40 (2): 114~121    
    4. 2010 "Genome-wide Response of Normal WI-38 Human Fibroblast Cells to 1,763 MHz Radiofrequency Radiation" Genomics & informatics 8 (1): 28~33    
    5. 2010 "Classification of Biological Effect of 1,763 MHz Radiofrequency Radiation Based on Gene Expression Profiles" Genomics & informatics 8 (1): 34~40    
  • Lee, Sang-Sup (28)

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