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S-Nitrosylation of Sulfhydryl Groups in Albumin by Nitrosating Agents

Park, Jeen-Woo    (Department of Biochemistry, College of Natural Sciences, Kyungpook National University  );
  • 초록

    The reaction of sulfhydryl groups in human serum ablumin with bacteriostatic and hypotensive notrosating agents such as sodium nitorprusside and sodium nitrite has been examined. The low reactivity of sodium nitroprusside to sulfhydral groups in albumin has been observed and the sterical inaccessilibility of the agent site which sulfhydryl group resides was implicated. The reaction of sodium nitrite with albumin was highly influenced by pH and little reactivity was observed at physiological pH. On the other hand, the reaction between albumin and S-nitrosoglutatione, an intermediate induced from the reaction of glutathione and nitrosating agents, resulted in the rapid decrease of free sulfhydryl groups in albumin. S-Nitrosylation of the sulfhydryl group by S-nitrosoglutathione and the subsequent production of mixed disulfide is the probable route of modification. In the physiological system, S-nitroso-glutathione may act as an active intermediate in expressing reacivity of nitrosating agents to sulfhydryl groups in albumin.


  • 주제어

    S-nitrosoglutathione .   S-nitrosylation .   Hypotensive agent .   Bacteriostatic agent.  

 저자의 다른 논문

  • Park, Jeen-Woo (9)

    1. 1989 "Formation of Nitrosamines from Sodium Nitroprusside and Physiological Amines" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 12 (4): 239~242    
    2. 1989 "An Unusually Stable S-Nitrosothiol from Glutathione" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 12 (4): 257~258    
    3. 1990 "Oxidative Damage to Bacterial DNA and Evicence for Its Repair" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 13 (3): 252~256    
    4. 1994 "Xanthine oxidase 활성 및 형전환에 미치는 구리이온의 영향" 약학회지 = Yakhak hoeji 38 (2): 211~217    
    5. 1997 "Antagonists of Phosphatidylinositol 3-Kinase Block Phosphorylation-Dependent Activation of the Leukocyte NADPH Oxidase in a Cell-Free System" Journal of biochemistry and molecular biology = 한국생화학회지 30 (3): 182~187    
    6. 1997 "Lipid Peroxidation Product-Mediated DNA Damage and Mutagenicity" Journal of biochemistry and molecular biology = 한국생화학회지 30 (3): 188~193    
    7. 1998 "Change in the Conformation of $p47^{phox}$ by Sodium Dodecyl Sulfate, an Activator of the Leukocyte NADPH Oxidase" Journal of biochemistry and molecular biology = 한국생화학회지 31 (3): 227~232    
    8. 1999 "Inactivation of Copper, Zinc Superoxide Dismutase by the Lipid Peroxidation Products Malondialdehyde and 4-Hydroxynonenal" Journal of biochemistry and molecular biology = 한국생화학회지 32 (5): 440~444    

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