본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Effects of Brazilin on Lipid and Phosphatidyl Fatty Acid Composition of Erythrocyte Membrane in Streptozotocin-induced Diabetic Rats

Moon, Change-Kiu    (College of Pharmacy, Seoul National University   ); Yoon, Eun-Yi    (College of Pharmacy, Seoul National University   ); Lee, Soo-Hwan    (College of Pharmacy, Seoul National University   ); Moon, Chang-hyun    (School of Medicine, Ajou University   ); Hwang, Daniel-H.    (Pennington Biomedical Research Center, Louisiana State University  );
  • 초록

    In diabetes, the abnormal increase of the membrane cholesterol/phospholipid ratio (C/PL) is consdered to be the main reason for the decreased membrane fluidity, which then results in impaired erythrocyte deformability and subsequent microcirculatory disturbances. In this study, we examined the effects of brazilin on lipid and phosphatidyl fatty acid composition of erythrocyte membranes in streptozotocin induced diabetic rats. Treatment of brazilin (10mg/kg or 100 mg/kg for 2 weeks, i.p) altered and cholesterol contents in diabetic erythrocyte membranes. The C/PL ratio of brazilin treated groups decreased compared with that of diabetic control group while no change was observed in normal erythrocytes. In streptozotocin induced diabetic rats, alterations in phosphatidyl fatty acid compositioin of erythrocyte membranes were observed and brazilin could reverse these alterations. Arachidonic acid level reumed to a normal level while linoleic acid level remained unchanged by the treatment of brazilin. The results suggest that brazilin might increase erythrocyte membrane fluidity which plays a key role inregulating erythrocyte deformability, thereby it could exert positive effects on microdiculatory disturbances.


  • 주제어

    Brazilin .   Erythrocyte .   Phospholipid .   Cholesterol .   Diabetes .   Fluidity .   Membrane lipid .   Phosphatidyl fatty acid composition.  

 저자의 다른 논문

  • 문창현 (27)

    1. 1990 "Effects of Brazilin on Glucose Metabolism in Primary Cultured Rat Hepatocytes" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 13 (4): 355~358    
    2. 1992 "Brazilin Inhibits Mitogen Inducedd Cell Proliferation Despite of Augmentation of T Cell Growth Factor (TCGF) Production and Expression of IL-2 Receptors" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 15 (4): 275~282    
    3. 1992 "Immunomodulating Activities of Brazilin in vitro" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 15 (4): 283~288    
    4. 1994 "Streptozotocin 유도 당뇨병 랫드의 혈소판 Phospholipase $A_2$ 활성에 미치는 Hydroxybrazilin의 영향" 약학회지 = Yakhak hoeji 38 (1): 97~101    
    5. 1994 "Effects of Brazilin on Glucose Metabolism in Epididymal Adipocytes from Streptozotocin induced Diabetic Rats" The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 2 (1): 65~70    
    6. 1995 "The Involvement of Protein Tyrosine Kinase in the Bacterial Lipopolysaccharide-Induced Arachidonic Acid Metabolism in Rat Alveolar Macrophages" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 18 (4): 262~266    
    7. 1995 "Effects of Crude Ginseng Saponin on the Thromboxane Synthesis in Lipopolysaccharide-stimulated Macrophages" The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 3 (4): 301~303    
    8. 1997 "정상 및 당뇨 흰쥐에서 주령과 절식에 의한 양파의 혈당조절작용 변화" The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 5 (4): 364~368    
    9. 1997 "일차 배양 혈관 평활근 세포에서 포도당 농도에 의한 엔도톡신 유도 프로스타글란딘 합성 변화" 약학회지 = Yakhak hoeji 41 (6): 782~788    
    10. 1997 "신규 합성 $K_{ATP}$ 통로 개방제인 SKP-450과 대사체 SKP-818의 흰쥐 적출 심장 및 대동맥에 대한 작용" 약학회지 = Yakhak hoeji 41 (2): 241~246    

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기