본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

The Action of Ginkgo Bibloba Extract in the Isolated Rabbit Corpus Cavernosum

Chung, Woo-Sik   (Department of Urology, Ewha Womans University College of MedicineUU0001056  ); Choi, Young-Deuk   (Department of Urology, Ewha Womans University College of MedicineUU0001056  ); Park, Young-Yo   (Department of Urology, Ewha Womans University College of MedicineUU0001056  ); Hah, Jong-Sik   (Department of Physiology, Ewha Womans University College of MedicineUU0001056  );
  • 초록

    The extract of Ginkgo bibloba (EGb) is a complex mixture of natural products from the Ginkgo leaves and clinically used for the treatment of cerebral and peripheral circulatory disturbances due to its combined activity of several vasoactive principles. In this study we investigated the action of EGb and its mechanism in isolated rabbit corporal smooth muscle to evaluate the possibility of using this material as a pharmacoerecting agent. Strips of rabbit corpus cavernosum were mounted in organ chambers to measure isometric tension. EGb began to exert an relaxing effect at 1 mg/ml in the submaximally precontracted muscle strips with phenylephrine $(PHE,\;5{\times}10^{-6}\;M)$ ; causing concentration-dependent relaxation with maximal effect at $3{\sim}5\;mg/ml$ . That relaxation was partially inhibited by removal of the smooth muscle endothelium or by pretreatment with a NO scavenger, pyrogallol $(10^{-4}\;M)$ or the guanylate cyclase inhibitor, methylene blue $(10^{-4}\;M)$ . Pretreatment with EGb (3 mg/ml) inhibited PHE- $(5{\times}10^{-6}\;M)$ or KCI- (20 and 40 mM) induced contraction of muscle strip. In calcium-free high potassium solution EGb depressed the basal tone of the depolarized muscle strip and inhibited calcium-induced contraction when $CaCl_2$ $(10^{-4}\;M)$ was added. These results suggest that EGb relaxes rabbit corpus cavernosal smooth muscle through multiple action mechanisms that include increasing the release of nitric oxide from the corporal sinusoidal endothelium, sequestration of intracytosolic calcium, and maybe a hyperpolarizing action.


  • 주제어

    Extract of Ginkgo bibloba .   Corporal smooth muscle.  

 저자의 다른 논문

  • Park, Young-Yo (1)

    1. 2005 "하향평가와 상향평가 결과에 영향을 미치는 특성 분석" 보건행정학회지 = Korean journal of health policy and administration 15 (1): 97~117    
  • 하종식 (13)

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • NDSL :
유료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기