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The Effects of Prolactin and Vasopressin on the Regulation of Amniotic Fluid Volume and Its $Na^{+}$ Concentration through the Membrane Surrounding Amniotic Fluid

Kim, Dong-Wook   (Department of Physiology & Biophysics, Seoul National University College of MedicineUU0000691  ); Kim, Sang-Jeong   (Department of Physiology & Biophysics, Seoul National University College of MedicineUU0000691  ); Sung, Ho-Kyung   (Department of Physiology & Biophysics, Seoul National University College of MedicineUU0000691  );
  • 초록

    The effects of prolactin and vasopressin on the regulation of amniotic fluid (AF) volume and its $Na^{+}$ concentration $([Na^{+}])$ through the membrane surrounding the AF during increase in AF volume due to fetal urination were studied. About 70% of AF volume was replaced with normal isotonic saline solution. Isotonic saline solution (0.5 ml) containing Censored and LiCl was introduced into each amniotic sac. Vasopressin (25 ng/ml) or prolactin (1 mg/ml) of AF was then injected into experimental amniotic sac. The concentrations of Congored, $Li^{+}$ , and $Na^{+}$ were measured at 30 and 60 min intervals after injection. Af samples with decreased Censored concentration ([CR]) during the period of 30 - 60 min were analyzed. The percentage change of $[Na^{+}]$ and the rate of $Li^{+}$ movement during this period were calculated, and the effects of vasopressin and prolactin on them were evaluated. Fellowing results were obtained: 1. The rate of reduction of [CR] in the AF was retarded by vasopressin or prolactin injection. 2. The rate of reduction of $[Li^{+}]$ in the AF was also retarded by vasopressin or prolactin injection. 3. The rate of reduction of $[Li^{+}]$ in the AF was less retarded by vasopressin than that of [CR]. 4. $[Na^{+}]$ changed to approach to the normal level, but this was markedly retarded by prolactin injection. 5. Direction of $Li^{+}$ movement was correlated with the change in $[Na^{+}]$ but it always moved out of the amniotic sac even when the $[Na^{+}]$ increased in vasopressin injected AF. From the above results, it is suggested that vasopressin in the AF triggers the fetus to urinate, and then the membranes surrounding the AF regulate osmolarity by efflux of $Na^{+}$ . We suggest that prolactin facilitates water outflow across the amniotic membrane during increase in AF volume, in contrast to a constant volume, whereas regulation of $[Na^{+}]$ is partly restricted by prolactin.


  • 주제어

    Amniotic membrane .   Amniotic fluid volume .   Amniotic fluid $Na^{+}$ concentration .   Prolactin .   Vasopressin.  

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  • Kim, Sang-Jeong (12)

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    2. 1992 "Electrophysiological Study on Medullospinal Tract Cells Related to Somatosympathetic Reflex in the Cat" 대한생리학회지 = Korean journal of physiology 26 (1): 75~88    
    3. 1992 "A Novel Therapeutic Measure for Metabolic Acidosis with Amino Acids" 대한생리학회지 = Korean journal of physiology 26 (1): 89~97    
    4. 1992 "Effect of Various Divalent Ions on the Calcium Current of Adrenal Medullary Chromaffin Cells in the Rat" 대한생리학회지 = Korean journal of physiology 26 (2): 113~122    
    5. 1993 "Cardiovascular Neurons Mediating Somatosympathetic Reflex in Rostral Ventrolateral Medulla" 대한생리학회지 = Korean journal of physiology 27 (2): 185~197    
    6. 1994 "Discharge Patterns and Peripheral Nerve Inputs to Cardiovascular Neurons in the Medulla of Cats: Comparison between the lateral and medial medulla" 대한생리학회지 = Korean journal of physiology 28 (2): 133~141    
    7. 1996 "Effects of Systemic and Focal Hypoxia on the Activities of Rostral Ventrolateral Medullary Neurons in Cats" 대한생리학회지 = Korean journal of physiology 30 (1): 105~116    
    8. 1997 "신생흰쥐 척수후근신경절 세포에서 전압의존성 $K^+$ 전류의 동정" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 1 (6): 613~624    
    9. 1998 "The Characterization of the Increase of Membrane Conductance after Depolarization in Single Rat Adrenal Chromaffin Cells" The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2 (1): 95~100    
    10. 1998 "심맥관계 활동과 관련있는 연수 척수로 세포에 작용하는 신경흥분전달물질에 대한 연구" 大韓胸部外科學會誌 = The Korean journal of thoracic and cardiovascular surgery 31 (5): 441~450    
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