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고려인삼학회지 = Korean journal of ginseng science v.20 no.4, 1996년, pp.389 - 415   피인용횟수: 47

고려인삼의 화학성분에 관한 고찰
Recent Studies on the Chemical Constituents of Korean Ginseng (Panax ginseng C. A. Meyer)

박종대    (한국인삼연초연구원  );
  • 초록

    Panax ginseng C.A. Meyer(Araliaceae) has been traditionally used as an expensive and precious medicine in oriental countries for more than 5, 000 years. Ginseng saponin isolated from the root of Panax ginseng have been regarded as the main effective components responsible for the pharmacological and biological activities. Such as antiaging effects. antidiabetic effects anticancer effects. Protection against physical and chemical stress. Analgesic and antipyretic effects. Effects on the central nervous system, tranquilizing action and others. Thirty kinds of ginsenosides have been so far isolated from ginseng saponin and their chemical structures have been elucidated since 1960's. Among which protopanaxadiol type is 19 kinds. protopanaxatriol type. 10 kinds and oleanane type, one. Since ginsenosides are generally labile under acidic conditions ordinary acid hydrolysis is always accompanied by many side reactions, such as epimerization. hydroxylation and cyclization of side chain of the sapogenins Especially. it is well known that C-20 glycosyl linkage of ginsenoside was hydrolysed on heating with acetic acid to give an equilibrated mixture of 20(S) and 20(R) epimers. And also, the chemical transformations of the secondary metabolites have appeared during the steaming process to prepare red ginseng. Indicating demalonylation of malonyl ginsenosides, elimination of glycosyl residue at C-20 and isomerization of hydroxyl configuration at C-20. But these studies have not provided a comprehensive picture in explaning how these ginsenosides showed val'iotas pharmacological activities of ginseng. Though some of them have been involved in the mechanism of pharmacological actions. Recently, non-saponin components have received a great deal of attention for their antioxidant, anticancer antidiabetic, immunomodulating. anticomplementary activities and so on. To meet the demand for such wide applications, studies on the non-saponin components play an important role in providing a good evidence of pharmacological and biol ogical activities. Among the non-saponin constituents of Korean ginseng, polyacetylenes, phenols. Sesquiterpenes, alkaloids. polysaccharides oligosaccharides, oligopeptides and aminoglycosides together with ginsenosides of terrestrial part are mainly described.


  • 주제어

    Pnax ginseng .   Araliaceae .   chemical constituents .   white ginseng .   red ginseng .   saponin .   non-saponin.  

  • 이 논문을 인용한 문헌 (47)

    1. 2000. "Patterns and Contents of Ginsenoside in Normal Root Parts and Hairy Root Lines of Panax ginseng C. A. Meyer" 식물조직배양학회지 = Korean journal of plant tissue culture, 27(6): 485~489     
    2. 2001. "" Journal of photoscience : an international journal officail organ of the korean society of photoscience, 8(1): 19~22     
    3. 2003. "Comparisons of Antidiabetic Activities between White Ginseng Ethanol Extract and IH-901 in Streptozotocin-Induced Diabetic Rats" 약학회지 = Yakhak hoeji, 47(1): 52~55     
    4. 2005. "" Food science and biotechnology, 14(4): 509~513     
    5. 2005. "" Food science and biotechnology, 14(4): 558~560     
    6. Ku, Kyung-Hyung ; Lee, Kyung-A ; Park, Wan-Soo 2006. "Qualify Characteristics of Baechukimchi Added Ginseng during Fermentation Periods" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 35(10): 1444~1448     
    7. Yang, Byung-Wook ; Han, Sung-Tai ; Ko, Sung-Kwon 2006. "Quantitative Analysis of Ginsenosides in Red Ginseng Extracted under Various Temperature and Time" 생약학회지, 37(4): 217~220     
    8. Lee, Sun-Mee ; Jung, Hyeon-A ; Joo, Na-Mi 2006. "Optimization of Iced Cookie with the Addition of Dried Red Ginseng Powder" 한국식품영양학회지 = The Korean journal of food and nutrition, 19(4): 448~459     
    9. In Jun-Gyo ; Lee Bum-Soo ; Kim Eun-Jeong ; Park Myung-Han ; Yang Deok-Chun 2006. "Increase of Functional Saponin by Acidic Treatemnt and Temperature of Red Ginseng Extract" 韓國資源植物學會誌 = Korean journal of plant resources, 19(1): 139~143     
    10. Hong, Hee-Do ; Kim, Young-Chan ; Rho, Jeong-Hae ; Kim, Kyung-Tack ; Lee, Young-Chul 2007. "Changes on Physicochemical Properties of Panax ginseng C. A. Meyer during Repeated Steaming Process" Journal of ginseng research = 高麗人參學會誌, 31(4): 222~229     
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    14. Kwon, Joong-Ho ; Kim, Kyo-Youn ; Kwon, Young-Ju ; Kim, Mi-Yeung ; Yoon, Sung-Ran ; Chung, Hun-Sik ; Lee, Ki-Teak ; Cho, Soon-Heang 2008. "Comparative Properties of Red Ginseng Prepared with Different Cultivation Years of Fresh Ginseng Produced in Punggi Region" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 37(1): 72~75     
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    19. 2009. "" Food science and biotechnology, 18(1): 253~256     
    20. Tark, Keun-Man ; Son, Min-Hee ; Chae, Hee-Jeong 2009. "Optimal Analytical Conditions for Panax Ginseng Ginsenosides using HPLC and Ginsenosides Content Analysis of Red Ginseng Products and their Raw Materials" 한국산학기술학회논문지 = Journal of the Korea Academia-Industrial cooperation Society, 10(2): 418~424     
    21. Kim, Mi-Hyun ; Lee, Young-Chul ; Choi, Sang-Yoon ; Cho, Chang-Won ; Rho, Jeong-Hae 2009. "Characteristics of Acid Pre-treated Red Ginseng and Its Decoction" Journal of ginseng research = 高麗人參學會誌, 33(4): 343~348     
    22. Kim, Hae-Ja ; Kim, Wan-Gyeom ; Cho, Hwa-Eun ; Choi, Yun-Hee ; Lee, Ki-Nam ; Chong, Myong-Soo 2009. "Study on Activities of Antioxidant and Anticancer of Germanium-fortified Tricholoma matsutake Myceliumm" 동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine, 23(2): 473~479     
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    24. Kang, Ho-Jin ; Kim, Seung-Hee ; Kum, Jun-Seok ; Lim, Jae-Kag 2010. "Effect of Ginseng Powder on Quality Characteristics of Instant Rice Cake (Baekseolgi)" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 39(3): 435~442     
    25. 2010. "" Journal of ginseng research = 高麗人參學會誌, 34(1): 1~7     
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    28. Cha, Bae-Cheon ; Yoon, Hye-Chul ; Lee, Dae-Ho ; Park, Jae-Seuk ; Kwon, Ki-Rok 2010. "Component analysis of cultivated ginseng and mountain ginseng to the change of ginsenoside components in the process of heating and fermentation." Journal of pharmacopuncture, 13(2): 33~49     
    29. 2010. "" Journal of ginseng research = 高麗人參學會誌, 34(2): 93~97     
    30. 2011. "" Journal of ginseng research = 高麗人參學會誌, 35(4): 497~503     
    31. 2011. "" Journal of ginseng research = 高麗人參學會誌, 35(1): 39~44     
    32. 2011. "" Journal of ginseng research = 高麗人參學會誌, 35(1): 60~68     
    33. Jeon, Young-Eun ; Kim, Jin-Kyung ; Yin, Xing-Fu ; Lee, Ju-Woon ; Nam, Jin-Sik ; Kang, Il-Jun 2011. "Oral Toxicity Study on the 90-day Repeated-dose of 50 kGy Irradiated Methanol Extract Powder of Red Ginseng" 한국식품영양과학회지 = Journal of the Korean Society of Food Science and Nutrition, 40(6): 824~831     
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    35. Yoon, Bo-Ra ; Lee, Young-Jun ; Hong, Hee-Do ; Lee, Young-Chul ; Kim, Young-Chan ; Rhee, Young Kyoung ; Kim, Kyung-Tack ; Lee, Ok-Hwan 2012. "Inhibitory Effects of Panax ginseng C. A. Mayer Treated with High Temperature and High Pressure on Oxidative Stress" 한국식품영양학회지 = The Korean journal of food and nutrition, 25(4): 800~806     
    36. Jung, Kyung Hee ; Hong, Hee-Do ; Cho, Chang-Won ; Lee, Min-Young ; Choi, Ung-Kyu ; Kim, Young-Chan 2012. "Phenolic Acid Composition and Antioxidative Activity of Red Ginseng Prepared by High Temperature and High Pressure Process" 한국식품영양학회지 = The Korean journal of food and nutrition, 25(4): 827~832     
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    38. Noh, Hyun-Ho ; Lee, Jae-Yun ; Park, So-Hyun ; Lee, Kwang-Hun ; Oh, Jae-Ho ; Im, Moo-Hyeog ; Kyung, Kee-Sung 2012. "Residual characteristics of azoxystrobin and difenoconazole in ginseng" 농약과학회지 = The Korean journal of pesticide science, 16(2): 131~136     
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    40. Kim, Na-Young ; Chae, Hyun-Seok ; Park, Sung-Jin ; Yoon, Deok-Ihn ; Seo, Kang-Tae ; Bae, Hyun-Soo 2012. "Investigation on the Perception of the Ginseng and Ginseng Products among University Students in Yeongsu, Gangwon-do" 한국식품영양학회지 = The Korean journal of food and nutrition, 25(3): 454~459     
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    44. Cho, Seong-Ah ; Yoo, Kyung-Mi ; Lee, Seul ; Kim, Kyung-Tak ; Hwang, In-Kyeong 2013. "Quality Characteristics of Nutrition Bar Substituted with Defatted Ginseng Seed Meal" 한국식품조리과학회지 = Korean Journal of Food & Cookery Science, 29(3): 249~256     
    45. Kang, Bok-Hee ; Lee, Kun-Jae ; Hur, Sang-Sun ; Lee, Dong-Sun ; Lee, Sang-Han ; Shin, Ki-Sun ; Lee, Jin-Man 2013. "Ginsenoside derivatives and quality characteristics of fermented ginseng using lactic acid bacteria" 한국식품저장유통학회지 = Korean journal of food preservation, 20(4): 573~582     
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    47. Im, Byung Ok ; Cho, Soon Hyun ; Ko, Sung Kwon 2014. "Changes in the Contents of Prosapogenin in the Skin White ginseng(Panax ginseng) Depending on Extracting Batches" 생약학회지, 45(4): 315~319     

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