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Anti-inflammatory Activity of Propolis

Park, Eun-Hee    (College of Pharmacy, Sookmyung Women's University   ); Kim, Sun-Hee    (College of Pharmacy, Sookmyung Women's Univeristy   ); Park, Soo-Sun    (College of Pharmacy, Sookmyung Women's University  );
  • 초록

    Propolid (bee-glue), known as a folk medicine, is a lipo;hilic material found in honeybee hives. In the present study on the anti-inflammatory effect of Korean propolis, it was extracted with ethanol, and used as a test material. The $LD_{50}$ value with the oral administration of ethanolic extract of Korean propolis (EEKP) was higher than 2g/kg in mice. The oral administration of the propolis extract (100mg/kg) significantly inhibited the development of hind paw edema induced by carrageenin in rats. the oral pretreatment of the propolis extract markedly inhibited the increase in vascular permeability and the number of writhing induced by acetic acetic acid in mice. Propolis extract, 50 and 100 mg/kg p.o. per day for 7 days, produced a significant inhibitory effect on granuloma and exudate formation in rats. This inhibitory effect was enhanced with the concomitant use of prednisolone (2.5 mg/kg). These results suggest that Korean propolis apparently has a strong anti-inflammatory activity.


  • 주제어

    KOREAN PROPOLIS .   ANIMAL MODEL .   ACUTE TOXICITY .   ANTI-INFLAMMATORY ACTIVITY .   ANALGESIC EFFECT.  

 저자의 다른 논문

  • Park, Eun-Hee (39)

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    2. 1991 "항코린에스테라제 활성에 대한 파파베린 및 디펜히드라민의 효과" 약학회지 = Yakhak hoeji 35 (5): 438~443    
    3. 1992 "Inhibitory Effect of Papaverine on the Contraction Induced by Transmural Stimulation in the Isolated Mouse Vas Deferens" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 15 (2): 134~137    
    4. 1993 "조각자 물추출물의 항염증 작용" 약학회지 = Yakhak hoeji 37 (2): 124~128    
    5. 1998 "Purification and Properties of Phenylalanine Ammonia-lyase from Chinese Cabbage" Journal of biochemistry and molecular biology = 한국생화학회지 31 (1): 31~36    
    6. 1998 "손바닥선인장의 항염증 활성" 약학회지 = Yakhak hoeji 42 (6): 621~626    
    7. 1998 "Thioltransferase (Glutaredoxin) from Chinese Cabbage: Purification and Properties" Journal of biochemistry and molecular biology = 한국생화학회지 31 (4): 377~383    
    8. 1998 "Activities of Sulfhydryl-Related and Phenylpropanoid-Synthesizing Enzymes during Leaf Development of Arabidopsis thaliana" Journal of biochemistry and molecular biology = 한국생화학회지 31 (6): 554~559    
    9. 1999 "A Second Thioltransferase of Schizosaccharomyces pombe Contains Glutathione S-transferase Activity" Journal of biochemistry and molecular biology = 한국생화학회지 32 (6): 535~540    
    10. 1999 "Suppressive Effects of Propolis in Rat Adjuvant Arthritis" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 22 (6): 554~558    
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