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Establishment of Doxorubicin-resistant Subline Derived from HCT15 Human Colorectal Cancer Cells

Choi, Sang-Un   (Pharmaceutical Screening Team, Korea Research Institute of Chemical TechnologyCC0186998  ); Kim, Nam-Young   (Pharmaceutical Screening Team, Korea Reserch Institute of Chemical Technology  ); Choi, Eun-Jung   (Pharmaceutical Screening Team, Korea Reserach Insitute of Chemical Technology  ); Kim, Kwang-Hee   (Pharmaceutical Screening Team, Korea Research Institute of Chemical TechnologyCC0186998  ); Lee, Chong-Ock   (Pharmaceutical Screening Team, Korea Research Institute of Chemical TechnologyCC0186998  );
  • 초록

    Doxorubicin, one of the clinically most useful anticancer agents, is used alone or in combination with other drugs against a wide variety of tumors, recently. But cancer cells developed resistance to this agent in many ways. This resistance is an important limiting factor of doxorubicin for anticancer drug. We newly established doxorubicin-resistant HCT15/CL02 subline from parental HCT15 human adenocarcinoma colon cancer cells. HCT15/CL02 revealed resistance to doxorubicin about 85-fold of its parental cells, and it also revealed cross-resistance to actinomycin D, etoposide and vinblastine but not to displatin and tamoxifen. And verapamil, a reversal agent of multidrug-resistance (MDR) by P-glycoprotein, elevated the cytotoxicity of doxorubicin against both HCT15 and GCT15/CL02 cells. But the relative resistant rate was not reduced. Verapamil had no effects on the tosicity of cisplatin to the both cell lines. These results indicate that HCT15/CL02 cells have some functionally complex mechanisms for MDR.


  • 주제어

    Doxorubicin-resistance .   Multidrug-resistance .   Human colon cancer .   P-glycoprotein .   Verapamil.  

  • 이 논문을 인용한 문헌 (2)

    1. 2002. "Isolation and Properties of Cytotoxic Polyene Antibiotics Produced by Myxococcus stipitatus JW117." 한국미생물·생명공학회지 = Korean journal of microbiology and biotechnology, 30(2): 157~161     
    2. 2004. "Isolation of Antibiotics Effective to Multidrug-Resistant Cancer Cells from Sorangium cellulosum(Myxobacteria)." 한국미생물·생명공학회지 = Korean journal of microbiology and biotechnology, 32(1): 47~51     

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  • 이정옥 (45)

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