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A Study on Flow Properties of Semisolid Dosage Forms

Shon, Sung-Gil    (College of Pharmacy, Pusan National University   ); Lee, Chi-Ho    (College of Pharmacy, Pusan National University  );
  • 초록

    There are a wide variety of semi-solid ointments used for healing the skin diseases, whose therapeutic and skin penetration abililties may greatly differ from one another depending on the compositions of ointment vehicles. A computer optimization technique was applied to obtain the optimum formula of o/w type ointment giving the in vitro maximum absorption rate through hairless rat skin membrane. Some of the formulations were selected to find out a relationship between skin penetration of ointment and its Theological characteristics. The experimental value of absorption rate obtained from the ointment by optimum formula agreed well with the theoretical value obtained from a polynomial regression analysis, Three kinds of ointments selected among 15 formulations were obtained with a concentric cylinder type rheometer (Model; Rheolab SM-HM Physica, Germany) at 20, 30, 40 and $50^{\circ}C$ for rheograms of rhelolgical properties of o/w type ointments. As the temperature was raised, all products showed a decrease in both shear stress and yield values. The higher skin penetration, the lower shear stress showed.


  • 주제어

    Indomethacin .   Hairless rat skin membrane .   Absorption rate .   Optimization .   Optimum formual .   Shear stress .   Rheogram.  

 저자의 다른 논문

  • 이치호 (32)

    1. 1984 "W/O/W 삼층막(三層膜) Microcapsules에 관(關)한 연구(硏究)" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 14 (2): 62~69    
    2. 1988 "Studies on Computer Optimization Techniques for Hydrophilic Vehicle Compositions" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 11 (3): 185~196    
    3. 1988 "프로필렌글리콜에서의 피록시캄의 안정성" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 18 (4): 203~208    
    4. 1990 "대두 지방산을 활용한 화장품 기초제 개발" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 20 (2): 55~64    
    5. 1991 "Studies on Corneal Penetration of P-Hydroxybenzoic Acid Esters" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 14 (4): 311~318    
    6. 1991 "케토코나졸의 고체분산계에 관한 연구" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 21 (1): 23~32    
    7. 1993 "Studies on Controlled Release of Indomethacin from PVA Hydrogel" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 16 (1): 43~49    
    8. 1993 "수용액중 [D-알라</TEX>$^2$</TEX>-메치오닌엔케팔린아미드의 안정성" The journal of applied pharmacology : the official journal of the Korean Society of Applied Pharmacology 1 (1): 31~36    
    9. 1994 "토끼의 각막 추출액 중 메치오닌엔케팔린 및 [D-알라$^2$-메치오닌엔케팔린아미드의 분해 및 안정화" 藥劑學會誌 = Journal of Korean pharmaceutical sciences 24 (1): 1~9    
    10. 1994 "A Study on the Absorption Mechanism of Drugs through Biomembranes" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 17 (3): 182~189    

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