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Antitumor Components of Agrocybe cylindracea

Hyun, Jin-won    (College of Pharmacy, Seoul National University   ); Kim, Chae-Kyun    (College of Pharmacy, Seoul National University   ); Park, Seol-Hee    (College of Pharmacy, Seoul National University   ); Yoon, Jong-Myung    (College of Pharmacy, Seoul National University   ); Shim, Mi-Ja    (Seoul City University   ); Kang, Chary-Yuil    (College of Pharmacy, Seoul National University   ); Choi, Eung-Chil    (College of Pharmacy, Seoul National University   ); Kim, Byong-Kak    (College of Pharmacy, Seoul National University  );
  • 초록

    To find pharmacologically active components of Agrocybe cylin(Iracea, its basidiocarps were extracted with water. The extracts were separated by DEAE cellulose column chromatography, Sepharose CL-4B gel filtration, and Concanavalin A-Sepharose 4B affinity chromatography. Among the obtained fractions from A, cylinclracea, fraction IN which was the neutral proteinbound-polysaccharide fraction exhibited a marked antitumor activity and it was tentatively named "Cylindan". It showed about 70% of tumor inhibition against the solid form of sarcoma 180 when a dose of 30 mg/kg/day was intraperitoneally injected into ICR mice. When each fraction was examined by chemical analysis, Cylindan consisted of 85% polysaccharide, 3% protein and 1% hexosamine. Its polysaccharide moiety contained glucose, mannose, fucose and galactose and its protein moiety contained the comparatively large amounts of aspartic acid and glycine, and other 11 amino acids.


  • 주제어

    Basidiomycete .   Agrocybe cylindracea .   Edible mushrooms .   Protein bound -po-lysaccharides .   Antitumor activity.  

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  • 김채균 (4)

    1. 1997 "표고버섯 영양요구성 변이주의 전기영동법에 의한 Isozyme 비교" 한국균학회지 = The Korean journal of mycology 25 (2): 85~90    
    2. 1997 "Characteristics of Artificial Hybrids between Lentinula edodes and Coriolus versicolor" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 20 (4): 384~386    
    3. 1997 "Protoplast fusion between Lentinula edodes and Coriolus versicolor" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 20 (5): 448~453    
    4. 2000 "Generation of Nucler Hybrids Overcoming the Natural Barrier of Incompatibility: Transfer of Nuclei from Lentinula edodes into Protoplasts of Coriolus versicolor" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 23 (1): 79~86    
  • 박설희 (7)

  • Yoon, Jong-Myung (3)

  • Choi, Eung-Chil (136)

  • 김병각 (162)

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