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A First Synthesis of Isofagar-idine:Topoisomerase I Inhibitor

Cho, Won-Jea    (Collegef of Pharmacy, Chonnam National University   ); Miyoji Hanaoka    (Faculty of Pharmaceutical Sciences, Kanazawa University  );
  • 초록

    We have reported the convenient biomimetic methodology for the synthesis of all kinds of substituent pattern benzo[c]phenanthridine alkaloids (Hanaoka et al., 1990; Hanaoka et al., 1991). Regioselective demethylation of C-8 position on oxyfagaridine (5), an intermediate for the synthesis of Fagaridine (4), would afford the precursor for the synthesis of Isofagaridine because the strong hydrogen bonding between amide and hydroxyl group of C-7 position probably resists to be reacted with week base and electrophiles. Thus, a selective alkylation of dihydroxy compound supposed to be possible and be lead to the target compound, Isofagaridine.


  • 주제어

    lsofagaridine .   Benzo[c]phenanthridine .   To-poisomerasr I,II inhibitors .   Cerium Ammonium Nitrate.  

  • 이 논문을 인용한 문헌 (1)

    1. 1996. "" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea, 19(4): 321~325     

 저자의 다른 논문

  • Cho, Won-Jea (19)

    1. 1996 "Synthesis of Benzo[c]phenanthridine Derivatives and their in Vitro Antitumor Activities" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 19 (4): 321~325    
    2. 1997 "Synthesis and Structure-Activity Relationship Studies of 2,3-Dihydroimidazo[2,1-a]isoquinoline Analogs as Antitumor Agents" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 20 (2): 138~143    
    3. 1997 "Synthesis and Antitumor Activity of 3-Arylisoquinoline Derivatives" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 20 (3): 264~268    
    4. 1997 "항진균제 알릴아민류의 합성과 생물학적 평가" 약학회지 = Yakhak hoeji 41 (2): 187~194    
    5. 1997 "항암제 안티네오플라스톤 A10의 동족체합성 및 항암 활성" 약학회지 = Yakhak hoeji 41 (3): 283~293    
    6. 1998 "Synthesis of Antineoplaston A10 Analogs as Potential Antitumor Agents" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 21 (2): 157~163    
    7. 1999 "새로운 2-(3-치환)프로피온산 유도체의 합성" 약학회지 = Yakhak hoeji 43 (3): 320~327    
    8. 1999 "Studies on the Synthesis and In Vitro Antitumor Activity of the Isoquinolone Derviatives" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 22 (2): 179~183    
    9. 1999 "Synthesis of Sesquiterpene Derivitives as Potential Antitumor Agents; Elemance Derivatives" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 22 (6): 575~578    
    10. 2000 "Effects of the Acute and Subacute Administration of 1-(N-methyl) piperazinyl-3-phenyl-isoquinoline on Rat Kidney" Journal of toxicology and public health : an official journal of the Korean Society of Toxicology 16 (1): 47~52    

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