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Inhibition of Tyrosine Hydroxylase by Palmatine

Lee, Myung-Koo    (College of Pharmacy, Chungbuk National University   ); Zhang, Yong-He    (College of Pharmacy, Chungbuk National University   ); Kim, Hack-Seang    (College of Pharmacy, Chungbuk National University  );
  • 초록

    Palmatine, an protoberberine isoquinoline alkaloid, has been found to inhibit dopamine biosynthesis by reducing tyrosine hydroxylase (TH) activity in PC12 cells (Lee and Kim, 1996). We have therefore investigated the effects of palmatine on bovine adrenal TH. Palmatine showed a mild inhibition on bovine adrenal TH (36.4% inhibition at concentration of $200\muM$ ). Bovine adrenal TH was inhibited competitively by palmatine with a substrate L-tyrosine. The Ki value was found to be 0.67 mM. This result suggests that the inhibition of TH activity by palmatine may be partially involved in the reduction of dopamine biosynthesis in PC12 cells.


  • 주제어

    Palmatine .   Bovine adernal .   Tyrosine .   hydroxylase .   L-tyrosine .   DL-6-methyl-5,6,7,8-tetrahydropterine .   Competivitve inhibition.  

  • 참고문헌 (17)

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    2. 1990 "Effect of Ginseng Saponin on the Analgesic Effect and Tolerance Development of Clonidine" 생약학회지 21 (1): 103~109    
    3. 1990 "Effects of cholane compounds on the development of morphine tolerance" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 13 (1): 38~42    
    4. 1993 "DNA Transfection in SK-N-BE(2)C Human Neuroblastoma Cells" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 16 (2): 155~157    
    5. 1994 "수종의 생약이 Bovine Adrenal Tyrosine Hydroxylase 및 Dopamine ${\beta}-Hydroxylase$ 활성에 미치는 영향 (II)" 생약학회지 25 (2): 194~197    
    6. 1994 "Inhibitory Effect of the Root of Coptis japonica on Catecholamine Biosynthesis in PC12 Cells" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 17 (4): 269~272    
    7. 1995 "수종의 생약이 PC12 Cells 중의 Catecholamines 생합성에 미치는 영향" 생약학회지 26 (1): 57~61    
    8. 1996 "Inhibitory Effects of the Stem Bark of Albizia julibrissin on Catecholamine Biosynthesis in PC12 Cells" 생약학회지 27 (2): 155~158    
    9. 1996 "Effects of the root of Polygala Tenuifolia on Catecholamine Biosynthesis in PC12 Cells" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 19 (1): 74~76    
    10. 1996 "Effects of Oxygen Free Radicals on Extracellular Glutamate Accumulation in Cultured Cells" Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea 19 (2): 132~136    
  • Zhang, Yong-He (1)

  • Kim, Hack-Seang (63)

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