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In Vitro Chemosensitivity Test of SK-302B on Human Colon Carcinoma Cell Lines

Kim, Soo-Kie    (Department of Microbiology, Wonju College of Medicine, Yonsei University   ); Ahn, Chan-Mug    (Department of Basic Sciences 1,2 Institute of Basic Medical Sciences, Wonju College of Medicine, Yonsei University   ); Kim, Tae-Ue    (Department of Medical Technology, College of Health Science, Yonsei University   ); Choi, Sun-Ju    (Department of Microbiology ,Wonju College of Medicine, Yonsei University   ); Park, Yoon-Sun    (Department of Microbiology ,Wonju College of Medicine, Yonsei University   ); Shin, Woon-Seob    (Department of Microbiology ,Wonju College of Medicine, Yonsei University   ); Koh, Choon-Myung    (Department of Microbiology, Wonju College of Medicine, Yonsei University  );
  • 초록

    SK-302B, an antibiotic purified from soil Streptomyces sp. 302, was structurally identified as echinomycin (C/sub 50/H/sub 66/N/sub 11/S/sub 2/). In the present experiment, the possibility of SK-302B as an anticolon cancer agent was investigated by using chemosensitivity system (MTT assay, clonogenic assay). Treatment of SK-302B on various colon cancer cell lines resulted in a significant cytotoxicity and tumor colony formation inhibition. These studies showed that SK-302B had a potent inhibition on colon cancer cells.


  • 주제어

    SK-302B .   Colon cancer cell line .   Chemosensitivity.  

  • 참고문헌 (16)

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  • Ahn, Chan Mug (7)

  • Kim, Tae-Ue (22)

  • 최선주 (17)

  • 고춘명 (52)

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