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Metabolism of glycyrrhizin and baicalin by human intestinal bacteria

Kim, Dong-Hyun   (College of Pharmacy, Kyung-Hee University  ); Jang, Il-Sung   (College of Pharmacy, Kyung-Hee University  ); Lee, Hyeong-Kyu   (Korean Research Institute of Bioscience and Biotechnology,KIST  ); Jung, Eun-Ah   (College of Pharmacy, Kyung-Hee University  ); Lee, Kyeu-Yup   (College of Pharmacy, Kyung-Hee University  );
  • 초록

    By human intestinal bacteria, glycyrrhizin (18 ${\beta}$ -glycyrrhetic acid ${beta}$ -D-glucuronyl. ${\alpha}$ -D-glucuronic acid, GL) and baicalin (baicalein ${\beta}$ -D-glucuronic acid) were metabolized to glycyrrhetinic acid and baicalin, respectively. However, . ${\alpha}$ -glucuronidase of Bacteroides JY-6 isolated from human intestinal bacteria hydrolyzed GL or 18. ${\beta}$ -glycyrrhetinic acid .. ${\alpha}$ -D-glucuronic acid to 18 ${\beta}$ -glycyrrhetic acid but did not baicalin. However, E. coli ${\beta}$ -glucironidase from human intestinal bacteria hydrolyzed baicalin to baicalein, but did not GL. ${\beta}$ -Glucuronidase of mammalian tissues hydrolyzed both GL and baicalin.


  • 주제어

    Glycyrrhizin .   lntesinal bacteria .   Baicalin Bacteriodes J-37.  

  • 참고문헌 (11)

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