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Bactericidal activities of LB20304, a new fluoroquinolone

Paek, Kyoung-Sook    (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd   ); Kim, Mu-Yong    (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd   ); Kim, In-Chull    (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd   ); Kwak, Jin-Hwan    (Biotech Research Institute, LG Chem Research Park, LG Chemical Ltd  );
  • 초록

    The time-kill curves of LB20304, a novel fluoroquinolone that has potent antibacterial activity against gram-positve and gram-negative bacteria, were calculated at the concentrations of 1/4-, 1/2-, 1-, 2- and 4-times the MIC against Staphylococcus aureus 77, Escherichia coli 3739E, Pseudomonas aeruginosa 1912E. The bactericidal activity of LB20304 for these strains was very rapid and comparable to that of ciprofloxacin. LB20304 produced a decrease in the $log_10$ CFU per milliliter of ${\geq}$ 3 within 2 h at 4-times the MIC for all strains and consitently prevented regrowth of bacteria after 24 h of incubation. The MBCs (Minimal Bactericidal Concentration) of LB20304 against test organisms were equal to or at most four-times higher than the MICs.


  • 주제어

    LB-20304 .   Fluoroquinolone .   Bactericidal activity .   Time-kill .   MBC.  

  • 참고문헌 (12)

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    5. In vitro activities of LB20304, a new fluoroquinolone , Kim,M.Y.;Oh,J.I.;Paek,K.S.;Hong,C.Y.;Kim,I.C.;Kwak,J.H. , Arch. Pharm. Res. / v.19,pp.52-59,
         
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    9. In vitro and in vivo antibacterial activities of LB20304, a new fluoronaphthyridone , Oh,J.I.;Paek,K.S.;Kim,M.Y.;Seo,S.M.;Lee,Y.H.;Hong,C.Y.;Nam,D.H.;Kim,Y.Z.;Kim,I.C.;Kwak,J.H. , In Abstracts of the 35th Interscience Conference on Antimicrobial agents and Chemotherapy / v.,pp.148,
    10. In vitro and in vivo evaluations of LB20304, a new fluoronaphthyridone , Oh,J.I.;Paek,K.S.;Ahn,M.J.;Kim,M.Y.;Hong,C.Y.;Kim,I.C.;Kwak,J.H. , Antimicrobial Agents and Chemotheraphy / v.40,pp.1564-1568,
    11. Multicenter evaluation of the in vitro activities of three new quinolones, sparfloxacin, CI-960 and PD-131,628 compared with the activity of ciprofloxacin against 5,252 clinical bacterial isolates , Fuchs,P.C.;Barry,A.L.;Pfaller,M.A.;Allen,S.D.;Gerlach,E.H. , Antimicrobial Agents and Chemotheraphy / v.35,pp.764-766,
    12. Factors affecting in vitro activity of LB20304, a new fluoroquinolone , Paek,K.S.;Ahn,M.J.;Kim,M.Y.;Kim,I.C.;Kwak,J.H. , Arch. Pharm. Res. / v.19,pp.143-147,
         

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