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Stability and Formation Mechanism for MLV liposomes with Phospholipid Film by Use of the Microfluidizer

Kim, In-Young   (Han-Kook Cosmetics Co.  ); Seo, Bong-Seok   (Han-Kook Cosmetics Co.  );
  • 초록

    The MLV liposomes have been developed in many drugs and cosmetics fields. The phospholipid base is made from ceramides, cholesterol, cholesteryl ester, lecithin, lanolin ester, and B-sitosterol, and surfactants are made by using (PEG)n-sitosterol(n=5) and K-cetyl phosphate. We made visicles stable by passing samples through Microfludizer and croated multilamellar vesicles to make MLV liposomes similar to the structure of men's skin. In order to make MLV liposomes, we created lipid membrane films which a mixure of phospholipid base and polyol group was reacted above Tc(95 $^{\circ}C$ ) by gelation for 3 hours. As the optimum conditions of Microfluidizer, we figured out 700 bar for the passing pressure of samples, 4 $0^{\circ}C$ for its temperature, and 3 times of frequency to pass through samples. Our MLV liposomes is stable on conditions of a low temperature(5 $^{\circ}C$ ) and a high temperature(45 $^{\circ}C$ ), which is not to be split in a large range. We produced our own moisturizing cream which has a good affinity to skin by means of this system.


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