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$LD_{50}$의 독성학적 고찰
Toxicological Evaluation of Median Lethal Dose $(LD_{50})$

박현선    (성균관대학교 약학대학   ); 홍채영    (성균관대학교 약학대학   ); 오진아    (성균관대학교 약학대학   ); 윤승천    (성균관대학교 약학대학   ); 이병무    (성균관대학교 약학대학  );
  • 초록

    This paper reviews the toxicological role of median lethal dose ( $LD_50$ ) based on animal and human data. Animal oral $LD_50$ values of eighty seven chemicals were collected and comparatively evaluated with human minimum toxic dose ( $TD_50$ ). In general, animal $LD_50$ values were much higher than human $TD_50$ . The ratios between $LD_50$ and TDlo were ranged from 0.01 and over 1000, suggesting safety factor of up to 1000 between humans and animals in the case of acute toxicity data. However, about 40% of chemicals investigated were within the ratio of 10. Although the cases (N=20) were small, $LD_50$ values of guinea pig were closer to human TDlo than those of other animal species. In interanimal species (rat, mouse, rabbit, dog), the ratios of $LD_50$ values were between 0.1 and 5 (up to 50-fold difference). When the data are analyzed by chemical strut-ares, human $TD_50$ values were very close to rat oral $LD_50$ values. These data suggest that rat oral $LD_50$ value might be a useful parameter predicting human TDlo and one animal species could be sufficient for acute toxicity test.


  • 주제어

    $LD_{50}$ .   Human minimum toxic dose .   Tdlo .   Safety factor.  

  • 참고문헌 (28)

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