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Comparision of Regulatory Action of cAMP and cGMP on the Activation of Neutrophil Responses

Han, Chang-Hwang   (Department of Pharmacology, College of Medicine, Chung-Ang UniversityUU0001197  ); Yoon, Young-Chul   (Department of Pharmacology, College of Medicine, Chung-Ang UniversityUU0001197  ); Shin, Yong-Kyoo   (Department of Pharmacology, College of Medicine, Chung-Ang UniversityUU0001197  ); Han, Eun-Sook   (Department of Pharmacology, College of Medicine, Chung-Ang UniversityUU0001197  ); Lee, Chung-Soo   (Department of Pharmacology, College of Medicine, Chung-Ang UniversityUU0001197  );
  • 초록

    The regulatory role of cyclic nucleotides in the expression of neutrophil responses has been examined. fMLP-stimulated superoxide production in neutrophils was inhibited by dibutyryl adenosine 3',5'-cyclic monophosphate (DBcAMP), histamine, adenosine + theophylline, cAMP elevating agents, and 8-bromoguanosine 3' ,5' -cyclic monophosphate (8-BrcGMP) and sodium nitroprusside, cGMP elevating agents. Staurosporine, a protein kinase C inhibitor, genistein, a protein tyrosine kinase inhibitor and chlorpromazine, a calmodulin inhibitor, inhibited superoxide production by fMLP, but they did not further affect the action of DBcAMP on the stimulatory action of fMLP. DBcAMP, histamine, adenosine+theophylline and genistein inhibited myeloperoxidease release evoked by fMLP, whereas BrcGMP, sodium nitroprusside and staurosporine did not affect it. The elevation of $[Ca^{2+}]_i$ evoked by fMLP was inhibited by genistein and chlorpromazine but was not affected by staurosporine. DBcAMP exerted little effect on the initial peak in $[Ca^{2+}]_i$ response to fMLP but effectively inhibited the sustained rise. On the other hand, BrcGMP significantly inhibited both phases. fMLP-induced $Mn^{2+}$ influx was inhibited by either DBcAMP or BrcGMP. These results suggest that fMLP-stimulated neutrophil responses may be regulated by cAMP more than cGMP. cAMP and cGMP appear not affect stimulated responses by direct protein kinase C activation. Their regulatory action on the stimulated neutrophil responses may be not influenced by other activation processes.


  • 주제어

    Cyclic nucleotides .   Protein kinase and calmodulin inhibitors .   Neutrophils.  

 저자의 다른 논문

  • 윤영철 (2)

    1. 1995 "Staurosporine과 Genistein이 C5a 또는 PMA에 의하여 활성화된 호중구에서의 Superoxide와 HOCl 생성에 나타내는 영향" The Korean journal of pharmacology : official journal of the Society of Pharmacology, Republic of Korea 31 (1): 115~122    
    2. 2007 "An Analysis of Reaction Time in the Perception of Korean and English Words Utilizing the E-Prime Program" 음성과학 = Speech sciences 14 (1): 63~72    
  • 신용규 (30)

  • 한은숙 (16)

  • Lee, Chung-Soo (28)

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